Purpose: To determine the clinical effectiveness of combining triple inhalation therapy with non-invasive ventilation in treating acute exacerbated chronic obstructive pulmonary disease (AECOPD). Methods: A total of 128 AECOPD patients admitted in the Department of Respiratory Medicine of our Hospital were involved in the study. Two groups of patients were used (64 patients per group). The study group was given triple inhalation therapy and non-invasive ventilation, while only non-invasive ventilation was given to the control group. The curative effects of the two treatments and their effects on arterial Pa-CO2 (partial pressure of carbon dioxide), pH and Pa-O2 (partial pressure of oxygen) were determined. Results: The study group showed significantly higher treatment effectiveness than the control group (p < 0.05). Post-treatment Pa-CO2, pH, Pa-O2, respiratory rate and heart rate differed significantly between the two groups (p < 0.05). Improvements in the five indices were more in the study group than in the control group (p < 0.05). Conclusion: Combining triple inhalation therapy with non-invasive ventilation in the treatment of AECOPD enhances therapeutic effect, improves pulmonary ventilation, and reduces side effects.