机构：[a]Innovation Center for Neurological Disorders, Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院神经疾病高创中心（北京学者工作室）神经内科[b]Department of Neurology, Duke University School of Medicine, Durham, NC, USA
The new National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease has been developed to accelerate drug discovery and offer a common structure and language to construct new Alzheimer's disease conceptual models. However, as a "complex" disease, a model based on systems-level understanding is needed to accommodate the complex, interacting etiologic pathways and the system-level changes associated with Alzheimer's disease pathogenesis and interventions that are currently known and which will be identified in the future. To accomplish this, the evolution of the structure of the research framework itself should be encouraged. (C) 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
基金：
National Key R&D Program of China [2017YFC1310102]; National Natural Science Foundation of China [81671040]; Beijing Municipal Science & Technology Commission [Z151100004015078]
第一作者机构：[a]Innovation Center for Neurological Disorders, Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[a]Innovation Center for Neurological Disorders, Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Yi Tang,Michael W. Lutz,Yi Xing.A systems-based model of Alzheimer's disease[J].ALZHEIMERS & DEMENTIA.2019,15(1):168-171.doi:10.1016/j.jalz.2018.06.3058.
APA：
Yi Tang,Michael W. Lutz&Yi Xing.(2019).A systems-based model of Alzheimer's disease.ALZHEIMERS & DEMENTIA,15,(1)
MLA：
Yi Tang,et al."A systems-based model of Alzheimer's disease".ALZHEIMERS & DEMENTIA 15..1(2019):168-171
医学