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New insight into the genes susceptible to asthma

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机构: [a]Key Laboratory of Genome Science and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, No. 7, Beitucheng West Road, 100029 Beijing, China [b]Department of Gastrointestinal Medical Oncology, University of Texas, M. D. Anderson Cancer Center, Houston, TX, United States [c]Center for Asthma Prevention and Control, Affiliated Children's Hospital, Capital Institute of Pediatrics, Beijing, China
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关键词: Asthma Candidate gene approach Immunological network Model constitution Systems biology

摘要:
There is considerable worldwide interest in identifying genes related to susceptibility to asthma. Progress has been slow in part because of the complexity and heterogeneity of the disease. Although at least 170 genes located on 10 chromosomes have been associated with or in linkage with asthma and asthma-related phenotypes, the majority of the reports have either been preliminary or the results have been controversial. In order to overcome the problems with the inherent complexity of asthma and methodological issues, the authors propose a strategy for identification of asthma susceptibility genes based on theories of systems biology and bioinformatics and candidate gene approach. © 2010 Informa Healthcare USA, Inc.

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出版当年[2009]版:
大类 | 4 区 医学
小类 | 4 区 过敏 4 区 呼吸系统
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 过敏 4 区 呼吸系统
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出版当年[2008]版:
Q4 ALLERGY Q4 RESPIRATORY SYSTEM
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Q3 RESPIRATORY SYSTEM Q3 ALLERGY

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