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Potential Application of MicroRNA Profiling to the Diagnosis and Prognosis of HIV-1 Infection

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收录情况： ◇ SCIE

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机构： [1]Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, China, [2]Beijing Key Laboratory for HIV/AIDS Research, Beijing, China, [3]Department of Dermatology, Xuanwu Hospital, Capital Medical University, Beijing, China, [4]Kanglin Biotech (Hangzhou) Co., Ltd., Zhejiang, China, [5]Department of Infectious Diseases and STDs, Tianjin Second People’s Hospital, Tianjin, China, [6]Department of Biochemistry and Microbiology, Marshall University School of Medicine, Huntington, WV, United States

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关键词： HIV-1 microRNA disease progression biomarker immune system

摘要：

MicroRNAs (miRNAs) were first identified in Caenorhabditis briggsae and later recognized as playing pivotal roles in a vast range of cellular activities. It has been shown that miRNAs are an important mechanism not only for host defense against virus but also for the establishment of viral infection. During human immunodeficiency virus type 1 (HIV-1) infection, host miRNA profiles are altered either as a host response against the virus or alternatively as a mechanism for the virus to facilitate viral replication and infection or to maintain latency. The altered miRNA profiles can be detected and quantified by various advanced assays, and potentially serve as more sensitive, accurate and cost-efficient biomarkers for HIV-1 diagnosis and disease progression than those detected by currently available standard clinical assays. Such new biomarkers are critical for optimizing treatment regimens. In this review, we focus on the potential application of miRNA profiling to the diagnosis of HIV-1 infection and the monitoring of disease progression.

基金：

基金编号： 2017ZX10202102-005-003 2017ZX10202101-004-001 2017ZX10202102-005-001 2017ZX10202102-005-004 81772165 81571973 17JL20 BZ0089

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中科院(CAS)分区：

出版当年[2017]版：

大类 | 2 区生物

小类 | 2 区微生物学

最新[2023]版：

大类 | 2 区

生物学

小类 | 3 区微生物学

JCR分区：

出版当年[2016]版：

Q1 MICROBIOLOGY

最新[2023]版：

Q2 MICROBIOLOGY

影响因子： 4 最新[2023版] 5.1 最新五年平均 4.076 出版当年[2016版] 4.526 出版当年五年平均 4.165 出版前一年[2015版] 4.019 出版后一年[2017版]

第一作者：

第一作者机构： [1]Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, China, [2]Beijing Key Laboratory for HIV/AIDS Research, Beijing, China,

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通讯作者：

通讯机构： [1]Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, China, [2]Beijing Key Laboratory for HIV/AIDS Research, Beijing, China, [3]Department of Dermatology, Xuanwu Hospital, Capital Medical University, Beijing, China,

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