机构：[1]Cerebrovascular Disease Research Institute, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院首都医科大学•脑血管病研究所[2]Stroke Center, Beijing Institute for Brain Disorders, Beijing, China[3]Beijing Key Laboratory of Hypoxia Conditioning Translational Medicine, Beijing, China[4]Department of Neurology, Inner Mongolia Baogang Hospital, Baotou, Inner Mongolia, China[5]China‐America Joint Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院中美神经科学研究所[6]Pittsburgh Institute of Brain Disorders & Recovery and Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania[7]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China神经外科首都医科大学宣武医院
Introduction The neuroprotective effects of hypothermia in acute ischemic stroke are well documented. However, the mechanisms involved in the effects remain to be clearly elucidated and the role of hypothermia on long-term white matter integrity after acute ischemic stroke has yet to be investigated. Aims Results To investigate the role of mild focal hypothermia on long-term white matter (WM) integrity after transient cerebral ischemia. Mild focal hypothermia treatment immediately after ischemic stroke significantly promotes WM integrity 28 days after the occlusion of the middle cerebral artery (MCAO) in mice. Higher integrity of white matter, lower activation of total microglia, less infarct volume, and better neurobehavioral function were detected in hypothermia-treated mice compared to normothermia-treated mice. Furthermore, we found that hypothermia could decrease detrimental M1 phenotype microglia and promote healthy M2 phenotype microglia. In vitro, results also indicated that hypothermia promoted oligodendrocytes differentiation and maturation after oxygen glucose deprivation. Conclusion Hypothermia promotes long-term WM integrity and inhibits neuroinflammation in a mouse model of ischemic brain injury.
基金：
the Natural Science Foundation of China,
Grant/Award Number: 81471209 and
81641055; Distinguished Professor of
Cheung Kong Scholars Program, Grant/
Award Number: T2014251; Beijing Municipal
Administration of Hospitals’ Mission Plan,
Grant/Award Number: SML20150802;
National Science Foundation for
Distinguished Young Scholars, Grant/Award
Number: 81325007
第一作者机构：[1]Cerebrovascular Disease Research Institute, Xuanwu Hospital, Capital Medical University, Beijing, China[2]Stroke Center, Beijing Institute for Brain Disorders, Beijing, China[3]Beijing Key Laboratory of Hypoxia Conditioning Translational Medicine, Beijing, China[4]Department of Neurology, Inner Mongolia Baogang Hospital, Baotou, Inner Mongolia, China
共同第一作者：
通讯作者：
通讯机构：[*]Xuanwu Hospital, Capital Medical University, Beijing, China.
推荐引用方式(GB/T 7714)：
Li‐Qiang Liu,Xiang‐Rong Liu,Jing‐Yan Zhao,et al.Brain-selective mild hypothermia promotes long-term white matter integrity after ischemic stroke in mice[J].CNS NEUROSCIENCE & THERAPEUTICS.2018,24(12):1275-1285.doi:10.1111/cns.13061.
APA：
Li‐Qiang Liu,Xiang‐Rong Liu,Jing‐Yan Zhao,Feng Yan,Rong‐Liang Wang...&Xun‐Ming Ji.(2018).Brain-selective mild hypothermia promotes long-term white matter integrity after ischemic stroke in mice.CNS NEUROSCIENCE & THERAPEUTICS,24,(12)
MLA：
Li‐Qiang Liu,et al."Brain-selective mild hypothermia promotes long-term white matter integrity after ischemic stroke in mice".CNS NEUROSCIENCE & THERAPEUTICS 24..12(2018):1275-1285
