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Therapeutic hypothermia for stroke: Where to go?

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收录情况： ◇ SCIE ◇ CPCI(ISTP)

作者：

机构： [a]Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, Beijing 100053, China [b]Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100053, China [c]Department of Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing 100053, China

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关键词： Hypothermia Ischemic stroke Neuroprotection

摘要：

Ischemic stroke is a major cause of death and long-term disability worldwide. Thrombolysis with recombinant tissue plasminogen activator is the only proven and effective treatment for acute ischemic stroke; however, therapeutic hypothermia is increasingly recognized as having a tissue-protective function and positively influencing neurological outcome, especially in cases of ischemia caused by cardiac arrest or hypoxic-ischemic encephalopathy in newborns. Yet, many aspects of hypothermia as a treatment for ischemic stroke remain unknown. Large-scale studies examining the effects of hypothermia on stroke are currently underway. This review discusses the mechanisms underlying the effect of hypothermia, as well as trends in hypothermia induction methods, methods for achieving optimal protection, side effects, and therapeutic strategies combining hypothermia with other neuroprotective treatments. Finally, outstanding issues that must be addressed before hypothermia treatment is implemented at a clinical level are also presented. (C) 2015 Elsevier Inc. All rights reserved.

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出版当年[2014]版：

大类 | 2 区医学

小类 | 2 区神经科学

最新[2023]版：

大类 | 2 区医学

小类 | 2 区神经科学

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出版当年[2013]版：

Q1 NEUROSCIENCES

最新[2023]版：

Q1 NEUROSCIENCES

影响因子： 4.6 最新[2023版] 4.8 最新五年平均 4.617 出版当年[2013版] 4.478 出版当年五年平均 4.645 出版前一年[2012版] 4.696 出版后一年[2014版]

第一作者：

第一作者机构： [a]Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, Beijing 100053, China

通讯作者：

通讯机构： [*1]Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing 100053, China.

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