机构:[1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China神经外科首都医科大学宣武医院[2]Department of Neurology, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China[3]Department of Neurology, the Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, China[4]Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI, USA[5]China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China中美神经科学研究所首都医科大学宣武医院
Ischemic stroke is a major cause of death and disability globally, and its incidence is increasing. The only treatment approved by the US Food and Drug Administration for acute ischemic stroke is thrombolytic treatment with recombinant tissue plasminogen activator. As an alternative, therapeutic hypothermia has shown excellent potential in preclinical and small clinical studies, but it has largely failed in large clinical studies. This has led clinicians to explore the combination of therapeutic hypothermia with other neuroprotective strategies. This review examines preclinical and clinical progress towards developing highly effective combination therapy involving hypothermia for stroke patients.
基金:
the China National Funds for Distinguished Youth Scientist (81325007),
Distinguished Professor of Cheung Kong Scholars Program (T2014251),
National Natural Science Foundation (81571114)
Wenzhou Municipal Sci-Tec Bureau Programs (Y20120154 and Y20140686)
Projects of International Cooperation and Exchanges NSFC (81620108011).
第一作者机构:[1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China[2]Department of Neurology, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China
通讯作者:
通讯机构:[*1]Wenzhou Medical University the Second Affiliated Hospital, China.[*2]Xuanwu Hospital, Capital Medical University, Beijing, China.
推荐引用方式(GB/T 7714):
Zheng Zhang,Linlei Zhang,Yuchuan Ding,et al.Effects of Therapeutic Hypothermia Combined with Other Neuroprotective Strategies on Ischemic Stroke: Review of Evidence[J].AGING AND DISEASE.2018,9(3):507-522.doi:10.14336/AD.2017.0628.
APA:
Zheng Zhang,Linlei Zhang,Yuchuan Ding,Zhao Han&Xunming Ji.(2018).Effects of Therapeutic Hypothermia Combined with Other Neuroprotective Strategies on Ischemic Stroke: Review of Evidence.AGING AND DISEASE,9,(3)
MLA:
Zheng Zhang,et al."Effects of Therapeutic Hypothermia Combined with Other Neuroprotective Strategies on Ischemic Stroke: Review of Evidence".AGING AND DISEASE 9..3(2018):507-522