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Effects of Therapeutic Hypothermia Combined with Other Neuroprotective Strategies on Ischemic Stroke: Review of Evidence

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机构: [1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China [2]Department of Neurology, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China [3]Department of Neurology, the Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, China [4]Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI, USA [5]China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China
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关键词: ischemic stroke neuroprotection therapeutic hypothermia combination therapy

摘要:
Ischemic stroke is a major cause of death and disability globally, and its incidence is increasing. The only treatment approved by the US Food and Drug Administration for acute ischemic stroke is thrombolytic treatment with recombinant tissue plasminogen activator. As an alternative, therapeutic hypothermia has shown excellent potential in preclinical and small clinical studies, but it has largely failed in large clinical studies. This has led clinicians to explore the combination of therapeutic hypothermia with other neuroprotective strategies. This review examines preclinical and clinical progress towards developing highly effective combination therapy involving hypothermia for stroke patients.

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出版当年[2017]版
大类 | 2 区 医学
小类 | 2 区 老年医学
最新[2023]版:
大类 | 2 区 医学
小类 | 3 区 老年医学
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出版当年[2016]版:
Q1 GERIATRICS & GERONTOLOGY
最新[2023]版:
Q1 GERIATRICS & GERONTOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

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第一作者机构: [1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China [2]Department of Neurology, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China
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通讯机构: [*1]Wenzhou Medical University the Second Affiliated Hospital, China. [*2]Xuanwu Hospital, Capital Medical University, Beijing, China.
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