机构：[1]School of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing, China[2]Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院内科系统老年医学科[3]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院神经科系统神经外科[4]Center for Evidence-Based Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院[5]Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China[6]BUAA-CCMU Advanced Innovation Center for Big Data-based Precision Medicine, Beihang University, Beijing, China
Introduction: The neuroprotection of acute ischemic stroke patients can be achieved by intra-arterial selective cooling infusion using cold saline, which can decrease brain temperature without influencing the body core temperature. This approach can lead to high burdens on the heart and decreased hematocrit in the scenario of loading a high amount of liquid for longtime usage. Therefore, autologous blood is utilized as perfusate to circumvent those side effects. Methods: In this study, a prototype instrument with an autologous blood cooling system was developed and further evaluated by a mathematical model for brain temperature estimation. Results: Hypothermia could be achieved due to the adequate cooling capacity of the prototype system, which could provide the lowest cooling temperature into the blood vessel of 10.5 degrees C at 25 rpm (209.7 +/- 0.8 ml/min). And, the core body temperature did not alter significantly (-0.7 similar to -0.2 degrees C) after 1-h perfusion. The cooling rate and temperature distributions of the brain were analyzed, which showed a 2 degrees C decrease within the initial 5 min infusion by 44 ml/min and 13.7 degrees C perfusate. Conclusion: This prototype instrument system could safely cool simulated blood in vitro and reperfuse it to the target cerebral blood vessel. This technique could promote the clinical application of an autologous blood perfusion system for stroke therapy.
基金：
Beijing Municipal Commission of Education [KM202010025023]; Beijing Nova Program [Z201100006820143]; National Natural Science Foundation of China [61975017, 82001257, 82027802, 82071468, 82102220, 82171278]; Natural Science Foundation of Beijing Municipality [721220]
第一作者机构：[1]School of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing, China[2]Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]School of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing, China[2]Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China[3]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China[5]Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China[6]BUAA-CCMU Advanced Innovation Center for Big Data-based Precision Medicine, Beihang University, Beijing, China[*1]School of Instrumentation and Optoelectronic Engineering, Beihang University, Xueyuan Road, No.35, Haidian District, Beijing 100191, China.
推荐引用方式(GB/T 7714)：
Jiang Miaowen,Li Ming,Gao Yuan,et al.The intra-arterial selective cooling infusion system: A mathematical temperature analysis and in vitro experiments for acute ischemic stroke therapy[J].CNS NEUROSCIENCE & THERAPEUTICS.2022,28(9):1303-1314.doi:10.1111/cns.13883.
APA：
Jiang, Miaowen,Li, Ming,Gao, Yuan,Wu, Longfei,Zhao, Wenbo...&Ji, Xunming.(2022).The intra-arterial selective cooling infusion system: A mathematical temperature analysis and in vitro experiments for acute ischemic stroke therapy.CNS NEUROSCIENCE & THERAPEUTICS,28,(9)
MLA：
Jiang, Miaowen,et al."The intra-arterial selective cooling infusion system: A mathematical temperature analysis and in vitro experiments for acute ischemic stroke therapy".CNS NEUROSCIENCE & THERAPEUTICS 28..9(2022):1303-1314
