机构：[1]School of Biomedical Engineering, Capital Medical University Beijing 100069, P. R. China[2]Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical, Capital Medical University, Beijing 100069, P. R. China[3]Xuanwu Hospital, Capital Medical University, Beijing 100053, P. R. China首都医科大学宣武医院[4]Tongzhou Maternal and Child Health Care Hospital of Beijing, Shanghai Jiao Tong University, Beijing 101100, P. R. China
The elevated intraocular pressure (IOP) is one of the important risk factors of glaucomatous optic nerve damage. The deformations of glaucomatous optic nerve head (ONH) due to the elevated IOP might lead to further damage to the optic nerve. The ONH deformations due to the elevated IOP depend on their geometry. Therefore, it is meaningful to investigate the relationship between geometrical parameters and the deformation of ONH. Firstly, the geometrical parameters of ONH were obtained by in vivo using spectral domain optical coherence tomography. Then, individual-specific three-dimensional (3D) models of ONH for glaucoma and normal subjects were established and the deformations of ONH were acquired by using finite element method. Furthermore, the thickness changes of retina and lamina cribrosa were calculated under different IOPs. Finally, correlations between geometrical parameters and the relative deformations of the human ONH were researched by using Spearman correlation. It was found that the relative thickness change of patient's retina was larger than that of normal subjects under the same condition. The correlation of several parameters, including cup area, and lamina cribrosa depth, with relative deformations of ONH had statistical significance.
基金：
This work was supported by the National Natural Science Foundation of China under Grant No. 31670964 and Natural Science Foundation of Beijing under Grant No. 7142024.
第一作者机构：[1]School of Biomedical Engineering, Capital Medical University Beijing 100069, P. R. China[2]Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical, Capital Medical University, Beijing 100069, P. R. China
推荐引用方式(GB/T 7714)：
WANG SHOUXIN,LIU LIU,DAI WEIJIA,et al.EFFECT OF GEOMETRICAL PARAMETERS ON THE DEFORMATIONS OF THE HUMAN OPTIC NERVE HEAD BASED ON INDIVIDUAL-SPECIFIC MODELS[J].JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY.2018,18(7):doi:10.1142/S0219519418400158.
APA：
WANG, SHOUXIN,LIU, LIU,DAI, WEIJIA,WANG, SHANA,MA, LIPING...&QIAN, XIUQING.(2018).EFFECT OF GEOMETRICAL PARAMETERS ON THE DEFORMATIONS OF THE HUMAN OPTIC NERVE HEAD BASED ON INDIVIDUAL-SPECIFIC MODELS.JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY,18,(7)
MLA：
WANG, SHOUXIN,et al."EFFECT OF GEOMETRICAL PARAMETERS ON THE DEFORMATIONS OF THE HUMAN OPTIC NERVE HEAD BASED ON INDIVIDUAL-SPECIFIC MODELS".JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY 18..7(2018)
