机构：[1]Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China,神经外科首都医科大学宣武医院[2]Center of Parkinson’s Disease, Beijing Institute for Brain Disorders, Beijing, China,[3]Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Capital Medical University, Beijing, China,[4]Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States
Background and purpose: Subthalamic nucleus deep brain stimulation (STN DBS) is well established for the treatment of advanced Parkinson's disease (PD), substantially improving motor symptoms, quality of life, and reducing the long-term need for dopaminergic medication. However, whether chronic STN DBS produces different effects on PD motor subtypes is unknown. This retrospective study aimed to evaluate the long-term effects of STN DBS on the PD motor subtypes. Methods: Eighty patients undergoing STN DBS were included. The Unified Parkinson's Disease Rating Scale (UPDRS) analysis was performed in "On" and "Off" medication/"On" and "Off" stimulation conditions. The patients were classified as akinetic-rigid type (ART), tremor-dominant type (TDT), and mixed type (MT) based on the preoperative UPDRS III subscores in the "Off" medication state. Preoperative and postoperative comparisons were performed. Results: After 4.9 years, STN DBS produced significant improvement in the UPDRS III total scores and subscores of tremor, rigidity, and bradykinesia in the "Off" medication state in the ART group, less improvement in the MT group, and the least improvement in the TDT group. The UPDRS II and III total scores and other subscores failed to improve during the "On" medication state. However, all groups improved substantially, and the improvement in tremor was sustained for both the "On" and "Off" medication states after years. Long-term STN DBS failed to improve swallowing and speech in all the subtypes. Conclusion: The data confirms that PD is heterogeneous. Long-term STN DBS produced the best effects on bradykinesia/rigidity in the "Off" medication state and on tremor in the "On" and "Off" medication states. There were differences in the response by each group, but some of the differences could be explained by the fact that more severe symptoms at baseline tend to have greater improvement. The findings support the idea that ART mainly involves the basal ganglia-thalamo-cortical pathway, whereas TDT involves a different circuit, likely the cerebellar-thalamo-cortical pathway.
基金：
National Natural Science Foundation of China [81171061, 81371256, 81361128012]; Intramural Program of the National Institute of Neurological Disorders and Stroke, National Institutes of Health, United States
第一作者机构：[1]Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China,
通讯作者：
通讯机构：[1]Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China,[2]Center of Parkinson’s Disease, Beijing Institute for Brain Disorders, Beijing, China,[3]Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Capital Medical University, Beijing, China,
推荐引用方式(GB/T 7714)：
Cuiping Xu,Ping Zhuang,Mark Hallett,et al.Parkinson's Disease Motor Subtypes Show Different Responses to Long-Term Subthalamic Nucleus Stimulation[J].FRONTIERS IN HUMAN NEUROSCIENCE.2018,12:doi:10.3389/fnhum.2018.00365.
APA：
Cuiping Xu,Ping Zhuang,Mark Hallett,Yuqing Zhang,Jianyu Li&Yongjie Li.(2018).Parkinson's Disease Motor Subtypes Show Different Responses to Long-Term Subthalamic Nucleus Stimulation.FRONTIERS IN HUMAN NEUROSCIENCE,12,
MLA：
Cuiping Xu,et al."Parkinson's Disease Motor Subtypes Show Different Responses to Long-Term Subthalamic Nucleus Stimulation".FRONTIERS IN HUMAN NEUROSCIENCE 12.(2018)
