当前位置: 首页 > 详情页

Follow-up of bilateral subthalamic deep brain stimulation for Parkinson's disease

文献详情

资源类型:

收录情况: ◇ CPCI(ISTP)

机构: [1]Capital Univ Med Sci, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China; [2]Beijing Neurosurg Inst, Beijing, Peoples R China; [3]China Med Univ, Dept Neurosurg, Shenyang, Peoples R China
出处:
ISSN:

关键词: deep brain stimulation subthalamic nucleus follow-up

摘要:
Purpose. To demonstrate the effects of bilateral subthalamic deep brain stimulation (STN-DBS) in the treatment of Parkinson's disease (PD) after 4-45 months' follow-up. Method. Between 04/01 and 12/04, 46 PD patients were operated on with bilateral STN-DBS. All of them were evaluated with Unified Parkinson's Disease Rating Scale (UPDRS) parts II-V before surgery and 4-45 months after surgery. The amelioration of miscellaneous symptoms and decrease of medication dose, respectively, were compared. Main side effects were observed. Findings. After surgery, both the score of activities of daily living (ADL) and the UPDRS motor score decreased significantly (p < 0.001). Among the PD symptoms, tremor was improved best. Rigidity, bradykinesia, axial symptoms, facial expression and dyskinesia were all improved, although to a lesser extent, while speech was not improved. Medication dose was decreased significantly (p < 0.001). According to the time of follow-up, 4 groups were classified (4-12 months, 11-24 months, 25-36 months and 37-45 months group). ADL, UPDRS motor score and dyskinesia subscore improvement were compared among these groups. No significant difference existed. No life threatening complications occurred. Main side effects included hypophonia, dyskinesia, confusion, depression. Conclusions. Bilateral STN-DBS is a satisfying surgical method for the treatment of advanced PD. It can improve the cardinal PD symptoms up to 45 months. Complications and side effects were rare and usually temporary or reversible.

语种:
被引次数:
WOS:
PubmedID:
第一作者:
第一作者机构: [1]Capital Univ Med Sci, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China; [2]Beijing Neurosurg Inst, Beijing, Peoples R China; [3]China Med Univ, Dept Neurosurg, Shenyang, Peoples R China
通讯作者:
通讯机构: [1]Capital Univ Med Sci, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China; [2]Beijing Neurosurg Inst, Beijing, Peoples R China; [3]China Med Univ, Dept Neurosurg, Shenyang, Peoples R China
推荐引用方式(GB/T 7714):
APA:
MLA:

资源点击量:16409 今日访问量:0 总访问量:869 更新日期:2025-01-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 首都医科大学宣武医院 技术支持:重庆聚合科技有限公司 地址:北京市西城区长椿街45号宣武医院