机构：[a]Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, China神经内科老年医学科首都医科大学宣武医院[b]Clinical Center for Parkinson’s Disease, Capital Medical University, Beijing, China[c]Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Key Laboratory for Parkinson’s Disease, Parkinson Disease Center of Beijing Institute for Brain Disorders, Beijing, China[d]National Clinical Research Center for Geriatrics Disorders, Beijing, China
Background and purpose. - Patients with Parkinson's disease (PD) have difficulty performing self-initiated movements. The neural mechanism of this deficiency remains unclear. In the present study, we used functional magnetic resonance imaging (fMRI) to investigate the functional connectivity of the subthalamic nucleus (STN) during self-initiated movement in patients with PD. Materials and methods. - fMRI were acquired from patients with PD and age- and sex-matched healthy control subjects during a self-initiated right hand tapping task. We selected the bilateral sensorimotor subregions of the STN as regions of interest for our connectivity analysis. Results and conclusions. - We found that the STN contralateral to voluntary hand movement exhibited enhanced connectivity with the midbrain, thalamus, putamen, and so on in patients with PD compared to control subjects. In contrast, the STN ipsilateral to the hand movement exhibited enhanced connectivity with the midbrain and insula in PD patients compared to control subjects. Connectivity between the STN contralateral to the hand movement and the primary motor cortex and supplementary motor area was positively correlated with the severity of bradykinesia. Our findings suggest that STN-related connectivity in the hyperdirect and indirect basal ganglia pathways is strengthened during self-initiated movement in patients with PD. These disrupted network connections may contribute to bradykinesia. (C) 2017 Elsevier Masson SAS. All rights reserved.
基金：
the National Sci-ence Foundation of China (81571228);
the Ministry of Science andTechnology (2016YFC1306503);
Beijing Municipal Administrationof Hospitals’ Mission Plan (SML20150803);
Beijing Munici-pal Science & Technology Commission(Z161100005116011),(Z171100000117013);
Beijing Municipal commission of Healthand Family Planning (PXM2017 026283 000002).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区医学
小类|3 区神经成像3 区核医学4 区临床神经病学
最新[2023]版：
大类|3 区医学
小类|3 区临床神经病学3 区核医学4 区神经成像
JCR分区：
出版当年[2016]版：
Q2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ2CLINICAL NEUROLOGYQ2NEUROIMAGING
最新[2023]版：
Q2CLINICAL NEUROLOGYQ2NEUROIMAGINGQ2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
第一作者机构：[a]Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, China
通讯作者：
通讯机构：[*1]Department of Neurobiology, Key Laboratory onNeurodegenerative Disorders of Ministry of Education, Beijing Institute of Geriatrics,Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
Qian Jia,Linlin Gao,Jiarong Zhang,et al.Altered functional connectivity of the subthalamic nucleus during self-initiated movement in Parkinson's disease[J].JOURNAL OF NEURORADIOLOGY.2018,45(4):249-255.doi:10.1016/j.neurad.2017.11.008.
APA：
Qian Jia,Linlin Gao,Jiarong Zhang,Tao Wu&Piu Chan.(2018).Altered functional connectivity of the subthalamic nucleus during self-initiated movement in Parkinson's disease.JOURNAL OF NEURORADIOLOGY,45,(4)
MLA：
Qian Jia,et al."Altered functional connectivity of the subthalamic nucleus during self-initiated movement in Parkinson's disease".JOURNAL OF NEURORADIOLOGY 45..4(2018):249-255
