Altered Whole-Brain Structural Covariance of the Hippocampal Subfields in Subcortical Vascular Mild Cognitive Impairment and Amnestic Mild Cognitive Impairment Patients
机构：[1]School of Biological Science and Medical Engineering, Beihang University, Beijing, China,[2]Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University, Beijing, China,[3]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China,[4]Department of Neurology, XuanWu Hospital, Capital Medical University, Beijing, China,神经内科首都医科大学宣武医院[5]Department of Neurology, Hongqi Hospital, Mudanjiang Medical University, Mudanjiang, China
The hippocampus plays important roles in memory processing. However, the hippo campus is not a homogeneous structure, which consists of several subfields. The hippocampal subfields are differently affected by many neurodegenerative diseases, especially mild cognitive impairment (MCI). Amnestic mild cognitive impairment (aMCI) and subcortical vascular mild cognitive impairment (svMCl) are the two subtypes of MCI. aMCI is characterized by episodic memory loss, and svMCl is characterized by extensive white matter hyperintensities and multiple lacunar infarctions on magnetic resonance imaging. The primary cognitive impairment in svMCI is executive function, attention, and semantic memory. Some variations or disconnections within specific large-scale brain networks have been observed in aMCI and svMCI patients. The aim of this study was to investigate abnormalities in structural covariance networks (SCNs) between hippocampal subfields and the whole cerebral cortex in aMCI and svMCI patients, and whether these abnormalities are different between the two groups. Automated segmentation of hippocampal subfields was performed with FreeSurfer 5.3, and we selected five hippocampal subfields as the seeds of SCN analysis: CA1, CA2/3, CA4/dentate gyrus (DG), subiculum, and presubiculum. SCNs were constructed based on these hippocampal subfield seeds for each group. Significant correlations between hippocampal subfields, fusiform gyrus (FFG), and entorhinal cortex (ERC) in gray matter volume were found in each group. We also compared the differences in the strength of structural covariance between any two groups. In the aMCI group, compared to the normal controls (NC) group, we observed an increased association between the left CA1/CA4/DG/subiculum and the left temporal pole. Additionally, the hippocampal subfields (bilateral CA1, left CA2/3) significantly covaried with the orbitofrontal cortex in the svMCl group compared to the NC group. In the aMCI group compared to the svMCI group, we observed decreased association between hippocampal subfields and the right FFG, while we also observed an increased association between the bilateral subiculum/presubiculum and bilateral ERC. These findings provide new evidence that there is altered whole-brain structural covariance of the hippocampal subfields in svMCl and aMCI patients and provide insights to the pathological mechanisms of different MCI subtypes.
基金：
National Natural Science Foundation of China (Grant No. 81622025, 81471731, 31371007, 81430037, 81771795 and 61633018),
the Fundamental Research Funds for the Central Universities (No. YWF-17-BJ-J-11),
National Key Research and Development Program of China (No. 2016YFC1306300).
第一作者机构：[1]School of Biological Science and Medical Engineering, Beihang University, Beijing, China,[2]Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University, Beijing, China,
共同第一作者：
通讯作者：
通讯机构：[1]School of Biological Science and Medical Engineering, Beihang University, Beijing, China,[2]Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University, Beijing, China,[3]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China,[4]Department of Neurology, XuanWu Hospital, Capital Medical University, Beijing, China,[5]Department of Neurology, Hongqi Hospital, Mudanjiang Medical University, Mudanjiang, China
推荐引用方式(GB/T 7714)：
Xuetong Wang,Yang Yu,Weina Zhao,et al.Altered Whole-Brain Structural Covariance of the Hippocampal Subfields in Subcortical Vascular Mild Cognitive Impairment and Amnestic Mild Cognitive Impairment Patients[J].FRONTIERS IN NEUROLOGY.2018,9(MAY):342.doi:10.3389/fneur.2018.00342.
APA：
Xuetong Wang,Yang Yu,Weina Zhao,Qiongling Li,Xinwei Li...&Ying Han.(2018).Altered Whole-Brain Structural Covariance of the Hippocampal Subfields in Subcortical Vascular Mild Cognitive Impairment and Amnestic Mild Cognitive Impairment Patients.FRONTIERS IN NEUROLOGY,9,(MAY)
MLA：
Xuetong Wang,et al."Altered Whole-Brain Structural Covariance of the Hippocampal Subfields in Subcortical Vascular Mild Cognitive Impairment and Amnestic Mild Cognitive Impairment Patients".FRONTIERS IN NEUROLOGY 9..MAY(2018):342
