机构：[a]Cerebrovascular Diseases Research Institute and Department of Neurology, Xuanwu Hospital of Capital Medical University, c神经内科首都医科大学?脑血管病研究所首都医科大学宣武医院[b]Department of Neurological Surgery, University of Wisconsin, Madison, WI, USA[c]Cellular and Molecular Pathology Graduate Program, University of Wisconsin, Madison, WI, USA[d]William S. Middleton VA Hospital, Madison, WI, USA[e]Beijing Institute for Brain Disorders and Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing 10053, China[f]Department of Neurology, University of Pittsburgh School of Medicine, PA, USA
Stroke is the number one cause of neurological dysfunction in adults and has a heavy socioeconomic burden worldwide. The etiological origins of ischemic stroke and resulting pathological processes are mediated by a multifaceted cascade of molecular mechanisms that are in part modulated by posttranscriptional activity. Accumulating evidence has revealed a role for microRNAs (miRNAs) as essential mediators of posttranscriptional gene silencing in both the physiology of brain development and pathology of ischemic stroke. In this review, we compile miRNAs that have been reported to regulate various stroke risk factors and pre-disease mechanisms, including hypertension, atherosclerosis, and diabetes, followed by an in-depth analysis of miRNAs in ischemic stroke pathogenesis, such as excitotoxicity, oxidative stress, inflammation, apoptosis, angiogenesis and neurogenesis. Since promoting or suppressing expression of miRNAs by specific pharmaceutical and non-pharmaceutical therapies may be beneficial to post-stroke recovery, we also highlight the potential therapeutic value of miRNAs in clinical settings. (C) 2017 Elsevier Ltd. All rights reserved.
基金：
the National Natural Science Foundation of China (81471340, 81571280)
Beijing Nova Programme (Z151100000315065)
partially supported by National Institutes of Health Grant NS095192
US Veterans Administration Merit Review Grant 1I01BX002985
第一作者机构：[a]Cerebrovascular Diseases Research Institute and Department of Neurology, Xuanwu Hospital of Capital Medical University, c
共同第一作者：
通讯作者：
通讯机构：[*1]Xuanwu Hospital of Capital Medical University, Department of Neurology, Cerebrovascular Diseases Research Institute, 100053, Beijing, China.[*2]Department of Neurological Surgery and cCellular and Molecular Pathology Graduate Program, University of Wisconsin, Madison, WI, USA.
推荐引用方式(GB/T 7714)：
Guangwen Li,Kahlilia C. Morris-Blanco,Mary S. Lopez,et al.Impact of microRNAs on ischemic stroke: From pre- to post-disease[J].PROGRESS IN NEUROBIOLOGY.2018,163:59-78.doi:10.1016/j.pneurobio.2017.08.002.
APA：
Guangwen Li,Kahlilia C. Morris-Blanco,Mary S. Lopez,Tuo Yang,Haiping Zhao...&Yumin Luo.(2018).Impact of microRNAs on ischemic stroke: From pre- to post-disease.PROGRESS IN NEUROBIOLOGY,163,
MLA：
Guangwen Li,et al."Impact of microRNAs on ischemic stroke: From pre- to post-disease".PROGRESS IN NEUROBIOLOGY 163.(2018):59-78
：
医学