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O-GlcNAcylation modulates PKA-CREB signaling in a manner specific to PKA catalytic subunit isoforms

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收录情况： ◇ SCIE

作者：
Nana Jin[a,b] * ; Denglei Ma [b,c] ; Jianlan Gu [a,b] ; Jianhua Shi [b] ; Xiaotao Xu [d] ; Khalid Iqbal [b] ; Cheng-Xin Gong [b] ; Fei Liu [a,b] ; Dandan Chu [a] ;
机构： [a]Key Laboratory of Neuroregeneration of Jiangsu Province and Ministry of Education of China, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu 226001, PR China [b]Department of Neurochemistry, Inge Grundke-Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA [c]Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing 100053, PR China [d]Medical School, Nantong University, Nantong, Jiangsu, 226001, PR China
出处：
DOI： 10.1016/j.bbrc.2018.02.053
ISSN：

关键词： Protein kinase A CREB O-GlcNAcylation Phosphorylation

摘要：
O-GlcNAcylation is a post-translational modification of proteins. Protein kinase A (PKA)-cAMP response element binding protein (CREB) signaling plays critical roles in multiple biological processes. Isoforms alpha and beta of PICA catalytic subunit (PKAc) and CREB are modified by O-GlcNAcylation. In the present study, we determined the role of O-GlcNAcylation in PKAc isoform-specific CREB signaling. We found that up regulation of O-GlcNAcylation enhanced CREB phosphorylation, but suppressed CREB expression in exogenous PKAc isoform-unspecific manner. PKAc isoforms affected exogenous expression of OGT or OGA and protein O-GlcNAcylation differently. Up-regulation of O-GlcNAcylation did not significantly affect net PKAc alpha-CREB signaling, but enhanced PKAc beta-CREB signaling. The role of O-GlcNAcylation in PKA-CREB signaling was desensitized by insulin treatment. This study suggests a role of O-GlcNAcylation in PKA-CREB signaling by affecting phosphorylation of CREB in a PKAc isoform-specific manner. (C) 2018 Elsevier Inc. All rights reserved.

基金：
Nantong University and the New York State Office for People with Developmental Disabilities (OPWDD), the National Natural Science Foundation of China (Grants 31671046 and 81300978), China Scholarship Council (201608110204), Undergraduate Training Program for Innovation and Entrepreneurship of Jiangsu Province (201710304113X), the Neural Regeneration Co-innovation Center of Jiangsu Province.
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外文
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PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类 | 3 区 生物
小类 | 4 区 生化与分子生物学 4 区 生物物理
最新[2023]版：
大类 | 3 区 生物学
小类 | 3 区 生物物理 4 区 生化与分子生物学
JCR分区：
出版当年[2016]版：
Q3 BIOPHYSICS Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版：
Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

影响因子： 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

第一作者：
第一作者机构： [a]Key Laboratory of Neuroregeneration of Jiangsu Province and Ministry of Education of China, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu 226001, PR China [b]Department of Neurochemistry, Inge Grundke-Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
通讯作者：
通讯机构： [a]Key Laboratory of Neuroregeneration of Jiangsu Province and Ministry of Education of China, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu 226001, PR China
推荐引用方式(GB/T 7714)：
Nana Jin,Denglei Ma,Jianlan Gu,et al.O-GlcNAcylation modulates PKA-CREB signaling in a manner specific to PKA catalytic subunit isoforms[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2018,497(1):194-199.doi:10.1016/j.bbrc.2018.02.053.
APA：
Nana Jin,Denglei Ma,Jianlan Gu,Jianhua Shi,Xiaotao Xu...&Dandan Chu.(2018).O-GlcNAcylation modulates PKA-CREB signaling in a manner specific to PKA catalytic subunit isoforms.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,497,(1)
MLA：
Nana Jin,et al."O-GlcNAcylation modulates PKA-CREB signaling in a manner specific to PKA catalytic subunit isoforms".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 497..1(2018):194-199

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