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Antenatal Taurine Improves Intrauterine Growth-Restricted Fetal Rat Brain Development Which Is Associated with Increasing the Activity of PKA-CaMKII/c-fos Signal Pathway

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机构： [a]Department of Neonatology, NICU, Bayi Children's Hospital, Southern Medical University, 5 Nanmen Cang, Dongcheng District, Beijing, 100700, China [b]Department of Neonatology and NICU, Shenzhen Baoan Maternal and Child Health Hospital, Shenzhen, China [c]Department of Pediatrics, 306th Hospital of PLA, Beijing, China

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关键词： c-fos Ca2+/calmodulin-dependent protein kinase II intrauterine growth restriction protein kinase A taurine

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This study aimed to explore whether antenatal supplement of taurine can improve the brain development of fetal rats with intrauterine growth restriction (IUGR) via protein kinase A (PKA)-Ca2+/calmodulin-dependent protein kinase II (CaMKII)/c-fos pathway. A total of 30 pregnant rats were randomly divided into the following three groups: control, IUGR, and IUGR with antenatal taurine supplementation groups. The expression of PKA, CaMKII, and c-fos mRNA and proteins in fetal rat brain tissues were detected by quantitative real time (qRT)-polymerase chain reaction (PCR) and Western blot, respectively; and the number of PKA-, CaMKII- and c-fos-positive cells was measured by immunohistochemistry. Western blot and qRT-PCR revealed that antenatal taurine supplementation significantly increased PKA, CaMKII, and c-fos protein and mRNA levels in fetal rats brain with IUGR (p < 0.05). Immunohistochemistry results showed that the numbers of PKA-, CaMKII-, and c-fos-positive cells were significantly decreased in the IUGR groups compared with the controls; while antenatal taurine could significantly increase the positive cell numbers (p < 0.05). So, we conclude that antenatal taurine improves IUGR fetal brain development which is associated with increasing the activity of PKA-CaMKII/c-fos signal pathway. © 2015 Georg Thieme Verlag KG Stuttgart New York.

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出版当年[2014]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区儿科

最新[2025]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区儿科

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