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Antenatal taurine improves neuronal regeneration in fetal rats with intrauterine growth restriction by inhibiting the Rho-ROCK signal pathway

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机构： [a]Department of Neonatology and NICU, Bayi Children’s Hospital Affiliated to Beijing Military General Hospital, 5 Nanmen Cang, Dongcheng District, Beijing, 100700, China [b]Graduate school of Anhui Medical University, Hefei, 230033, China [c]Graduate School of Southern Medical University, Guangzhou, 510515, China

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关键词： Intrauterine growth restriction Rho-ROCK signal pathway Taurine

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The Rho-ROCK signal pathway is an important mediator of inhibitory signals that blocks central nervous cell regeneration. Here, we investigated whether antenatal taurine improved neuronal regeneration in fetal rats with intrauterine growth restriction (IUGR) by inhibiting this pathway. Thirty pregnant rats were randomly divided into three groups: control, IUGR, and IUGR + antenatal taurine supplementation (taurine group). The mRNA levels of Ras homolog gene A (Rho A), Rho-associated coiled-coil forming protein kinase 2 (ROCK2), and proliferating cell nuclear antigen (PCNA) were detected using real-time quantitative PCR. RhoA, ROCK2 and PCNA-positive cells were counted using immunohistochemistry. Antenatal taurine supplementation decreased RhoA and Rock2 mRNA expression, increased PCNA mRNA expression, and significantly decreased RhoA, ROCK2-positive and increased PCNA-positive cell counts in IUGR fetal rat brain tissues (p < 0.05). Thus, antenatal taurine supplementation inhibited the expression of key Rho-ROCK signal molecules and improved IUGR fetal brain development. © 2014, Springer Science+Business Media New York.

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出版当年[2013]版：

大类 | 3 区医学

小类 | 4 区内分泌学与代谢 4 区神经科学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区神经科学 4 区内分泌学与代谢

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