From pregnancy to parturition, Sprague-Dawley rats were daily administered a low protein diet to establish a model of intrauterine growth restriction. From the 12th day of pregnancy, 300 mg/kg rine was daily added to food until spontaneous delivery occurred. Brain tissues from normal neonatal rats at 6 hours after delivery, neonatal rats with intrauterine growth restriction, and neonatal rats with intrauterine growth restriction undergoing taurine supplement were obtained for further experiments. The terminal deoxyribonucleotidyl transferase (TdT)-mediated biotin-16-dUTP nick-end labeling assay revealed that the number of apoptotic cells in the brain tissue of neonatal rats with intrauterine growth restriction significantly increased. Taurine supplement in pregnant rats reduced cell apoptosis in brain tissue from neonatal rats with intrauterine growth restriction. nohistochemical staining revealed that taurine supplement increased glial cell line-derived neurotrophic factor expression and decreased caspase-3 expression in the cerebral cortex of intrauterine growth-restricted fetal rats. These results indicate that taurine supplement reduces cell apoptosis through the glial cell line-derived neurotrophic factor-caspase-3 signaling pathway, resulting in a protective effect on the intrauterine growth-restricted fetal rat brain.
语种：
外文
中科院(CAS)分区：
出版当年[2012]版：
大类|4 区医学
小类|4 区细胞生物学4 区神经科学
最新[2023]版：
大类|2 区医学
小类|3 区细胞生物学3 区神经科学
第一作者：
第一作者机构：[1]Department of Neonatology and NICU of Bayi Children's Hospital, General Hospital of Beijing Military Command, Beijing 100700, China
推荐引用方式(GB/T 7714)：
Liu J,Wang X,Liu Y,et al.Antenatal taurine reduces cerebral cell apoptosis in fetal rats with intrauterine growth restriction[J].NEURAL REGENERATION RESEARCH.2013,8(23):doi:10.3969/j.issn.1673-5374.2013.23.009.
