机构:[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China神经内科首都医科大学宣武医院[2]Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China低氧适应转化医学北京市重点实验室首都医科大学宣武医院[3]Beijing Municipal Geriatric Medical Research Center, Beijing, China[4]National Clinical Research Center for Geriatric Disorders, Beijing, China
Chronic remote ischemic conditioning (RIC), particularly long-term repeated RIC, has been applied in clinical trials with the expectation that it could play its protective roles for protracted periods. In sports medicine, chronic RIC has also been demonstrated to improve exercise performance, akin to improvements seen with regular exercise training. Therefore, chronic RIC may mimic regular exercise, and they may have similar underlying mechanisms. In this study, we explored the common underlying mechanisms of chronic RIC and physical exercise in protecting multiple organs and benefiting various populations, the advantages of chronic RIC, and the challenges for its popularization. Intriguingly, several underlying mechanisms of RIC and exercise have been shown to overlap. These include the production of many autacoids, enhanced ability for antioxidant activity, modulating immune and inflammatory responses. Therefore, it appears that chronic RIC, just like regular exercise, has beneficial effects in unhealthy, sub-healthy and healthy individuals. Compared with regular exercise, chronic RIC has several advantages, which may provide novel insights into the area of exercise and health. Chronic RIC may enrich the modes of exercise, and benefit individuals with severe diseases. Also, the disabled, and sub-healthy individuals are likely to benefit from chronic RIC either as an alternative to exercise or an adjunct to pharmacological or non-pharmacological therapy.
基金:
The National Science Fund for Distinguished Young Scholars (No. 81325007),
Chang Jiang Scholars Program (No. T2014251), National Key R&D Program of China (No. 2017YFC1308405),
Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding (ZYLX201706)
The Capital Health Research and Development of Special (2016-4-1032).
第一作者机构:[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China[2]Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China
共同第一作者:
通讯作者:
通讯机构:[*1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China, 100053
推荐引用方式(GB/T 7714):
Wenbo Zhao,Sijie Li,Changhong Ren,et al.Chronic Remote Ischemic Conditioning May Mimic Regular Exercise: Perspective from Clinical Studies[J].AGING AND DISEASE.2018,9(1):165-171.doi:10.14336/AD.2017.1015.
APA:
Wenbo Zhao,Sijie Li,Changhong Ren,Ran Meng&Xunming Ji.(2018).Chronic Remote Ischemic Conditioning May Mimic Regular Exercise: Perspective from Clinical Studies.AGING AND DISEASE,9,(1)
MLA:
Wenbo Zhao,et al."Chronic Remote Ischemic Conditioning May Mimic Regular Exercise: Perspective from Clinical Studies".AGING AND DISEASE 9..1(2018):165-171