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Dissection of prodromal Alzheimer's disease

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收录情况： ◇ SCIE

作者：

机构： [1]Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, P. R. China, [2]Department of Neurology, the First Hospital of Tsinghua University, Beijing, P. R. China, [3]School of Medical Sciences, Faculty of Medicine, UNSW Australia, New South Wales, Australia, [4]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, P. R. China, [5]National Clinical Research Center for Geriatric Disorders, Beijing, P. R. China, [6]Beijing Institute of Geriatrics, Beijing, P. R. China, [7]PKU Care Rehabilitation Hospital, Beijing, P. R. China

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关键词： Alzheimer's disease Prodromal Biomarkers Neuroimaging Cerebrospinal Fluid Support Vector Machine Clinical Management Review

摘要：

Pathophysiological changes of Alzheimer's Disease (AD) begin decades before clinical symptoms become apparent, providing an important window for early diagnosis and intervention Prodromal stage of AD, a great opportunity for effective treatment and postponing the disease onset, has drawn extensive attention. The application of different biomarkers including neuroimaging, biochemical substances and genes makes AD-related pathology detectable in vivo and exploring novel biomarkers with relatively non-invasive and low cost has intrigued a wide range of interests. To identify individuals with high risk of conversion to AD and apply the research concept of prodromal AD into clinical practice, the utility of various biomarkers for distinguishing prodromal AD is evaluated in this review. Additionally, clinical management focusing on the stage of prodromal AD is summarized in this review for dementia prevention.

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中科院(CAS)分区：

出版当年[2017]版：

大类 | 3 区生物

小类 | 3 区生化与分子生物学 4 区细胞生物学

最新[2025]版：

大类 | 4 区生物学

小类 | 4 区生化与分子生物学 4 区细胞生物学

JCR分区：

出版当年[2016]版：

Q3 CELL BIOLOGY Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 CELL BIOLOGY

影响因子： 3.3 最新[2023版] 3.6 最新五年平均 2.497 出版当年[2016版] 2.758 出版当年五年平均 2.484 出版前一年[2015版] 2.349 出版后一年[2017版]

第一作者：

第一作者机构： [1]Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, P. R. China, [2]Department of Neurology, the First Hospital of Tsinghua University, Beijing, P. R. China,

通讯作者：

通讯机构： [*1]Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing 100053, China,

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