机构：[a]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China神经内科首都医科大学宣武医院[b]National Clinical Research Center for Geriatric Disorders, Capital Medical University, Beijing, China[c]Department of Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院[d]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China放射科首都医科大学宣武医院[e]Banner Alzheimer’s Institute Phoenix, AZ, USA
Frontotemporal dementia with parkinsonism-linked to chromosome 17 (FTDP-17) is a rare autosomal dominant neurodegenerative disorder. Most patients with FTDP-17 carry the mutation in the microtubule-associated protein tau (MAPT) gene. Striatum is predominantly and early affected in FTDP-17. Five family members (two symptomatic patients and three presymptomatic mutation carriers) from a Chinese pedigree of FTDP-17 with N279K mutation in MAPT were enrolled. Parkinsonism was the initial symptom for symptomatic patients. 2b-carbomethoxy-3b-(4-trimethylstannylphenyl) tropane (C-11-CFT) uptake was obviously affected in the putamen of two presymptomatic mutation carriers. Presymptomatic case 3, whose C-11-CFT uptake in the right putamen was normal at baseline, was still free of parkinsonism during follow-up. In conclusion, C-11-CFT-positron emission tomography could be a potential biomarker for the presymptomatic stage of FTDP-17 to predict the disease onset.
基金：
the National Natural Science Foundation of China (No. 81470074, 81601099),
Clinical funding from Beijing Municipal Science and Technology Committee (Z141107002514117),
Beijing Municipal Government Funding (PXM 2017 026283 000002),
Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry ([2015] No.1098);
Beijing Talents Fund (2015000026833ZK06);
Beijing Municipal Administration of Hospitals Youth Program (QML20150801);
Clinical-Basic Medicine Cooperation Fund of Capital Medical University (16JL28).
第一作者机构：[a]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China[b]National Clinical Research Center for Geriatric Disorders, Capital Medical University, Beijing, China[*1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Changchun Street 45, Beijing 100053, China.
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Changchun Street 45, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
Liyong Wu,Jia Liu,Xueyan Feng,et al.C-11-CFT-PET in Presymptomatic FTDP-17: A Potential Biomarker Predicting Onset[J].JOURNAL OF ALZHEIMERS DISEASE.2018,61(2):613-618.doi:10.3233/JAD-170561.
APA：
Liyong Wu,Jia Liu,Xueyan Feng,Jing Dong,Wei Qin...&Jianping Jia.(2018).C-11-CFT-PET in Presymptomatic FTDP-17: A Potential Biomarker Predicting Onset.JOURNAL OF ALZHEIMERS DISEASE,61,(2)
MLA：
Liyong Wu,et al."C-11-CFT-PET in Presymptomatic FTDP-17: A Potential Biomarker Predicting Onset".JOURNAL OF ALZHEIMERS DISEASE 61..2(2018):613-618
