Age-dependent elevations of oligomeric and phosphorylated alpha-synuclein synchronously occurs in the brain and gastrointestinal tract of cynomolgus monkeys
机构：[a]Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China首都医科大学宣武医院[b]Clinical Center for Parkinson’s Disease, Capital Medical University, China[c]Center of Parkinson’s Disease, Beijing Institute for Brain Disorders, Beijing, China[d]Beijing Key Laboratory for Parkinson’s Disease, Beijing, China[e]Laboratory of Neuroscience, Affiliated Hospital of Guilin Medical University, Guilin, China
Fibrillary alpha-synuclein (alpha-syn), which constitutes the major component of Lewy pathology characterized for Parkinson's disease (PD), is found also in the aged enteric nervous system (ENS) and central nervous system (CNS). However, what happens to oligomeric alpha-syn (o-alpha-syn) in the aged ENS and CNS remains poorly understood. Here, by using ELISA methods specific for o-alpha-syn and phosphorylated alpha-syn (p-alpha-syn), we measured the levels of o-alpha-syn and p-alpha-syn in the gastrointestinal (GI) tract and brain of aging cynomolgus monkeys. We detected a synchronously occurred age-dependent elevation of o-alpha-syn in the GI tract and brain, which was accompanied by an age-dependent increase of alpha-syn phosphorylated at serine 129, a modification that promotes a-syn aggregation. Correlation analysis revealed that alterations in p-alpha-syn and o-alpha-syn in the colon were positively correlated to those in some brain regions such as the striatum, hippocampus, thalamus and temporal lobe. The results obtained suggest that age-dependent elevations of p-alpha-syn and o-alpha-syn occur synchronously in various regions of the ENS and CNS.
基金：
Natural Science Foundation of China (81671244, 81371200, and 81401042),
Beijing Municipal Science & Technology Commission (Z161100005116011, Z171100000117013),
Beijing Municipal commission of Health and Family Planning (PXM2017_026283_000002).
第一作者机构：[a]Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China[b]Clinical Center for Parkinson’s Disease, Capital Medical University, China[d]Beijing Key Laboratory for Parkinson’s Disease, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Neurobiology, Xuanwu Hospital of China Capital Medical University, 45 Changchun Street, Beijin 100053, China.
推荐引用方式(GB/T 7714)：
Xin Li,Weiwei Yang,Xuran Li,et al.Age-dependent elevations of oligomeric and phosphorylated alpha-synuclein synchronously occurs in the brain and gastrointestinal tract of cynomolgus monkeys[J].NEUROSCIENCE LETTERS.2018,662:276-282.doi:10.1016/j.neulet.2017.10.047.
APA：
Xin Li,Weiwei Yang,Xuran Li,Min Chen,Chengwei Liu&Shun Yu.(2018).Age-dependent elevations of oligomeric and phosphorylated alpha-synuclein synchronously occurs in the brain and gastrointestinal tract of cynomolgus monkeys.NEUROSCIENCE LETTERS,662,
MLA：
Xin Li,et al."Age-dependent elevations of oligomeric and phosphorylated alpha-synuclein synchronously occurs in the brain and gastrointestinal tract of cynomolgus monkeys".NEUROSCIENCE LETTERS 662.(2018):276-282
