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Different patterns of longitudinal brain and spinal cord changes and their associations with disability progression in NMO and MS

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收录情况： ◇ SCIE

作者：
Yaou Liu[1,2,3,4] * ; Yunyun Duan[1] ; Jing Huang[1] ; Zhuoqiong Ren[1] ; Zheng Liu[5] ; Huiqing Dong[5] ; Florian Weiler[6] ; Horst K. Hahn[6] ; Fu-Dong Shi [4] ; Helmut Butzkueven[7] ; Frederik Barkhof[3,8] ; Kuncheng Li[1,2] ;
机构： [1]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, People’s Republic of China [2]Beijing Key Lab of MRI and Brain Informatics, Beijing 100053, People’s Republic of China [3]Department of Radiology and Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam 1007 MB, The Netherlands [4]Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, People’s Republic of China [5]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, People’s Republic of China [6]Fraunhofer MEVIS, Institute for Medical Image Computing, Universitatsallee 29, Bremen 28359, Germany [7]Department of Medicine, University of Melbourne, Parkville 3010, Australia [8]Institutes of Neurology and Healthcare Engineering, UCL, London, UK
出处：
DOI： 10.1007/s00330-017-4921-x
ISSN：

关键词： Multiple sclerosis Neuromyelitis optica Mean upper cervical cord area Brain MRI

摘要：
To investigate the longitudinal spinal cord and brain changes in neuromyelitis optica (NMO) and multiple sclerosis (MS) and their associations with disability progression. We recruited 28 NMO, 22 MS, and 20 healthy controls (HC), who underwent both spinal cord and brain MRI at baseline. Twenty-five NMO and 20 MS completed 1-year follow-up. Baseline spinal cord and brain lesion loads, mean upper cervical cord area (MUCCA), brain, and thalamus volume and their changes during a 1-year follow-up were measured and compared between groups. All the measurements were also compared between progressive and non-progressive groups in NMO and MS. MUCCA decreased significantly during the 1-year follow-up in NMO not in MS. Percentage brain volume changes (PBVC) and thalamus volume changes in MS were significantly higher than NMO. MUCCA changes were significantly different between progressive and non-progressive groups in NMO, while baseline brain lesion volume and PBVC were associated with disability progression in MS. MUCCA changes during 1-year follow-up showed association with clinical disability in NMO. Spinal cord atrophy changes were associated with disability progression in NMO, while baseline brain lesion load and whole brain atrophy changes were related to disability progression in MS. aEuro cent Spinal cord atrophy progression was observed in NMO. aEuro cent Spinal cord atrophy changes were associated with disability progression in NMO. aEuro cent Brain lesion and atrophy were related to disability progression in MS.

基金：
the ECTRIMS-MAGNMIS Fellowship from ECTRIMS, the National Natural Science Foundation of China (Grant Nos. 81571631 and 81401377), the Beijing Natural Science fund (Grant No. 7162077), the Beijing Nova Program (Grant No. xx2013045), the Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (Grant No. ZYLX201609).
语种：
外文
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中科院(CAS)分区：
出版当年[2017]版：
大类 | 2 区 医学
小类 | 2 区 核医学
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 核医学
JCR分区：
出版当年[2016]版：
Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版：
Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

影响因子： 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

第一作者：
第一作者机构： [1]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, People’s Republic of China [2]Beijing Key Lab of MRI and Brain Informatics, Beijing 100053, People’s Republic of China [3]Department of Radiology and Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam 1007 MB, The Netherlands [4]Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, People’s Republic of China
通讯作者：
通讯机构： [1]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, People’s Republic of China [2]Beijing Key Lab of MRI and Brain Informatics, Beijing 100053, People’s Republic of China [3]Department of Radiology and Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam 1007 MB, The Netherlands [4]Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, People’s Republic of China
推荐引用方式(GB/T 7714)：
Yaou Liu,Yunyun Duan,Jing Huang,et al.Different patterns of longitudinal brain and spinal cord changes and their associations with disability progression in NMO and MS[J].EUROPEAN RADIOLOGY.2018,28(1):96-103.doi:10.1007/s00330-017-4921-x.
APA：
Yaou Liu,Yunyun Duan,Jing Huang,Zhuoqiong Ren,Zheng Liu...&Kuncheng Li.(2018).Different patterns of longitudinal brain and spinal cord changes and their associations with disability progression in NMO and MS.EUROPEAN RADIOLOGY,28,(1)
MLA：
Yaou Liu,et al."Different patterns of longitudinal brain and spinal cord changes and their associations with disability progression in NMO and MS".EUROPEAN RADIOLOGY 28..1(2018):96-103

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