详情页 - 首都医科大学宣武医院知识库

当前位置：首页 > 详情页

Low-Dose Tirofiban Improves Functional Outcome in Acute Ischemic Stroke Patients Treated With Endovascular Thrombectomy

文献详情

资源类型：

WOS体系：

收录情况： ◇ SCIE

作者：

机构： [1]Department of Neurology,Xuanwu Hospital, Capital Medical University, Beijing, China [2]Department of Neurosurgery,Xuanwu Hospital, Capital Medical University, Beijing, China [3]Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA [4]Department of Neurology, Medical University of South Carolina, Charleston

出处：

DOI：

ISSN：

关键词： atherosclerosis cerebral hemorrhage platelet aggregation thrombectomy tirofiban

摘要：

Background and Purpose-Chinese patients largely experience acute ischemic stroke (AIS) because of large artery atherosclerosis rather than cardioembolism, and whether tirofiban is safe and effective in these patients treated with endovascular thrombectomy (ET) is unknown. This study evaluated the safety and efficacy of tirofiban in Chinese patients with AIS treated with ET. Methods-This observational study is based on a single-center prospective registry study. Patients with AIS undergoing ET with second-generation stent retrievers from January 2013 to February 2017 were treated with ET alone or ET plus low dose of tirofiban. The primary outcome was symptomatic intracerebral hemorrhage (sICH). The secondary outcomes included rate of early reocclusion, any ICH, fatal ICH, and 3-month and long-term functional outcomes. Results-One hundred eighty AIS subjects were included in the analysis, including 90 subjects treated with tirofiban and 90 subjects without tirofiban. Sixty-three subjects (35%) had any ICH, 19 of them (11%) were sICH, and 9 of them (5%) were fatal ICH. Ten subjects (11%) treated with tirofiban experienced sICH and 9 subjects (10%) not given tirofiban experienced sICH, not a significant difference (P=0.808). Early reocclusion happened in 4 of 90 subjects (4.4%) treated with tirofiban and 8 of 90 subjects (8.9%) not treated with tirofiban (P=0.370). One hundred sixty-one subjects (89%) completed long-term follow-up, subjects treated tirofiban were associated with lower odds of death (23% versus 44%, P=0.005) when compared with those who were not treated. Additionally, tirofiban was associated with better odds of long-term functional independence (adjusted odds ratio, 4.37; 95% confidence interval, 1.13-16.97; P=0.033). Conclusions-In patients with AIS undergoing ET, tirofiban is not associated with higher sICH, it seems to lead to lower odds of deaths and better odds of long-term functional independence. Further investigations are needed to determine the efficacy of tirofiban in preventing early reocclusion, the underlying mechanisms, and its optimal treatment protocol.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2016]版：

大类 | 2 区

医学

小类 | 2 区临床神经病学 2 区外周血管病

最新[2023]版：

大类 | 1 区

医学

小类 | 1 区临床神经病学 1 区外周血管病

JCR分区：

出版当年[2015]版：

Q1 PERIPHERAL VASCULAR DISEASE Q1 CLINICAL NEUROLOGY

最新[2023]版：

Q1 CLINICAL NEUROLOGY Q1 PERIPHERAL VASCULAR DISEASE

影响因子： 7.9 最新[2023版] 8.2 最新五年平均 5.787 出版当年[2015版] 6.308 出版当年五年平均 5.761 出版前一年[2014版] 6.032 出版后一年[2016版]

第一作者：

第一作者机构： [1]Department of Neurology,Xuanwu Hospital, Capital Medical University, Beijing, China

共同第一作者：

通讯作者：

通讯机构： [*1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, No. 45, Changchun St, Xicheng District, Beijing 100053, China

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]The Prediction of Hemorrhage Transformation by Cerebral Autoregulation in AIS Patient After Endovascular Thrombectomy [2]Safety and efficacy of different tirofiban administration routes on acute ischemic stroke patients with successful recanalization: A propensity score matching analysis [3]重症脑出血患者个体化血糖管理的临床意义及预后* [4]Relationship Between Plasma Inflammatory Markers and Platelet Aggregation in Patients With Clopidogrel Resistance After Angioplasty [5]抗血小板聚集药物的机制研究进展 [6]Inhibition of shear-induced platelet aggregation by Chinese herbal medicines [7]不调整血小板数量检测血小板聚集率更适合监测抗血小板药物疗效 [8]AoGDW肽抑制血小板聚集的作用机制 [9]血细胞分析仪未检出血小板分布宽度的原因分析及该类标本血小板计数准确性评价 [10]Rescue Tirofiban During Mechanical Thrombectomy for Acute Ischemic Stroke Patients With Bridging Intravenous Thrombolysis.