We evaluated the relationship between plasma inflammation markers and clopidogrel resistance in patients after stent implantation. The plasma levels of C-reactive protein (CRP), P-selectin, platelet soluble CD40 ligand (sCD40L), interleukin 6 (IL-6) and platelet aggregation were measured in 352 patients undergoing percutaneous coronary intervention (PCI) at baseline and after 6 months. The plasma levels of CRP, P-selectin, sCD40L, IL-6 was higher in 65 (18.5%) patients with clopidogrel resistance than in those with normal responsiveness at 6 months after PCI. There was a significant positive correlation between soluble CD40L levels and platelet aggregation (r = .28, P < .05). Diabetes (DM) and sCD40L level were independent predictors for unresponsiveness after stent implantation according to stepwise multivariate analyses. The hazard ratio (HR) for sCD40L level was 3.02 (95% CI = 1.28 to 3.25; P = .036) and for DM 2.53 (95% CI = 1.28 to 6.55, P = .03). We conclude that sCD40L and DM may influence clopidogrel resistance.
第一作者机构：[1]Capital Med Univ, Dept Cardiol, Anzhen Hosp, Ward 12, Beijing 100029, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Dept Cardiol, Anzhen Hosp, Ward 12, Beijing 100029, Peoples R China
推荐引用方式(GB/T 7714)：
Ge Hailong,Zhou Yujie,Liu Xiaoli,et al.Relationship Between Plasma Inflammatory Markers and Platelet Aggregation in Patients With Clopidogrel Resistance After Angioplasty[J].ANGIOLOGY.2012,63(1):62-66.doi:10.1177/0003319711406432.
APA：
Ge, Hailong,Zhou, Yujie,Liu, Xiaoli,Nie, Xiaomin,Wang, Zhijian...&Yang, Qing.(2012).Relationship Between Plasma Inflammatory Markers and Platelet Aggregation in Patients With Clopidogrel Resistance After Angioplasty.ANGIOLOGY,63,(1)
MLA：
Ge, Hailong,et al."Relationship Between Plasma Inflammatory Markers and Platelet Aggregation in Patients With Clopidogrel Resistance After Angioplasty".ANGIOLOGY 63..1(2012):62-66
