Lipidomic analysis reveals the significant increase in diacylglycerophosphocholines in umbilical cord blood from pregnant women with gestational hypercholesterolemia
机构：[a]School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, China[b]Xuanwu Hospital, Capital Medical University, Beijing 100023, China首都医科大学宣武医院
Gestational hypercholesterolemia has been recognized as a risk factor of some pregnancy complications. We supposed that maternal hypercholesterolemia modified the lipid profile of the fetus. Thirty pregnant women with hypercholesterolemia and matched controls were recruited and cord blood was sampled. Lipidomic analysis was used to evaluate the lipid profile change between the two groups. The results showed that the content of diacylglycerophosphocholines (PC) was significantly high in cord blood from hypercholesterolemic pregnant women. PC (16: 0/20: 4) and PC (18: 0/20: 4) were selected as the most important lipid species in cord plasma and their contents were positively related to the total cholesterol and high-density lipoprotein cholesterol levels in cord blood. The contents of these two PCs were significantly higher in the hypercholesterolemic group than in the control group. These results suggested that gestational hypercholesterolemia might program the phospholipid metabolism in offspring. (C) 2017 Elsevier Ltd. All rights reserved.
基金：
the National Natural Science Foundation of China (Grant No. 81273070)
the project for the construction of a contingent of teachers in Beijing (PXM2015_014226_000066).
第一作者机构：[a]School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, China
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Nutrition and Food Hygiene School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, China.
推荐引用方式(GB/T 7714)：
Ran Zhang,Qi Zhou,Xueping Cai,et al.Lipidomic analysis reveals the significant increase in diacylglycerophosphocholines in umbilical cord blood from pregnant women with gestational hypercholesterolemia[J].PLACENTA.2017,59:39-45.doi:10.1016/j.placenta.2017.08.004.
APA：
Ran Zhang,Qi Zhou,Xueping Cai,Shan Dong,Zhiyin Le...&Huanling Yu.(2017).Lipidomic analysis reveals the significant increase in diacylglycerophosphocholines in umbilical cord blood from pregnant women with gestational hypercholesterolemia.PLACENTA,59,
MLA：
Ran Zhang,et al."Lipidomic analysis reveals the significant increase in diacylglycerophosphocholines in umbilical cord blood from pregnant women with gestational hypercholesterolemia".PLACENTA 59.(2017):39-45
