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MicroRNA-322 attenuates aluminum maltolate-induced apoptosis in the human SH-SY5Y neuroblastoma cell line

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收录情况： ◇ SCIE

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机构： [1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053 [2]School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069 [3]Human Anatomy Division, Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China

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关键词： microRNA-322 aluminum-maltolate apoptosis V-Myc avian myelocytomatosis viral oncogene homolog Alzheimer's disease

摘要：

Aluminum-maltolate (Al-Malt) is a potent apoptosis inductor, which has been widely reported as an etiologic factor in Alzheimer's disease (AD). MicroRNA-322 (miR-322) is a vital regulator in various biological processes. The aim of the current study was to identify the role and possible underlying mechanism of miR-322 in Al-Malt-induced apoptosis. Eight concentrations of Al-Malt were prepared and used for treating the human neuroblastoma cell line, SH-SY5Y. Subsequent to treatment with Al-Malt for 3 days, cell viability, apoptosis and the expression levels of apoptosis-associated factors were measured. In addition, the mRNA expression level of miR-322 was monitored. Furthermore, cells were transfected with an miR-322 mimic and/or treated with Al-Malt, and cell viability, apoptosis and the expression levels of apoptosis-associated factors were measured again. Al-Malt significantly inhibited cell viability, but promoted apoptosis. The apoptosisassoci-ated factors, V-Myc avian myelocytomatosis viral oncogene homolog (c-Myc), Bcl-2-associated X protein, caspase-3 and cleaved caspase-3 were markedly upregulated by Al-Malt. The mRNA expression level of miR-322 was negatively regulated by Al-Malt. Furthermore, miR-322 attenuated the apoptosis induced by Al-Malt and recovered the expression changes of these four factors. Thus, miR-322 may attenuate Al-Malt-induced apoptosis by recovering the expression change of c-Myc. Furthermore, miR-322 may be involved in the pathogenesis of Al-Malt-associated AD.

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出版当年[2016]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验 4 区肿瘤学

最新[2023]版：

大类 | 3 区医学

小类 | 4 区医学：研究与实验 4 区肿瘤学

JCR分区：

出版当年[2015]版：

Q3 MEDICINE, RESEARCH & EXPERIMENTAL Q4 ONCOLOGY

最新[2023]版：

Q2 ONCOLOGY Q2 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 3.4 最新[2023版] 3 最新五年平均 1.559 出版当年[2015版] 1.617 出版当年五年平均 1.554 出版前一年[2014版] 1.692 出版后一年[2016版]

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第一作者机构： [1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053

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通讯作者：

通讯机构： [*]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, N45 Changchun Street, Xicheng, Beijing 100053, P.R. China

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