机构：[1]Department of Neurobiology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing 100053, China首都医科大学宣武医院[2]Center of Parkinson’s Disease, Beijing Institute for Brain Disorders, Beijing, China[3]Beijing Key Laboratory for Parkinson’s Disease, Beijing, China
Parkinson's disease (PD), dementia with Lewy Bodies (DLB), and multiple system atrophy (MSA) are three major synucleinopathies characterized by alpha-synuclein-containing inclusions in the brains of patients. Because the cell types and brain structures that are affected vary markedly between the disorders, the patients have different clinical manifestations in addition to some overlapping symptoms, which are the basis for differential diagnosis. Cognitive impairment and depression associated with hippocampal dysfunction are frequently observed in these disorders. While various alpha-synuclein-containing inclusions are found in the hippocampal formation, increasing evidence supports that small alpha-synuclein aggregates or oligomers may be the real culprit, causing deficits in neurotransmission and neurogenesis in the hippocampus and related brain regions, which constitute the major mechanism for the hippocampal dysfunctions and associated neuropsychiatric manifestations in synucleinopathies.
基金：
the National Basic Research Program ("973"Program) of China (2011CB504101),
the Natural Science Foundation of China (81371200, 81071014, 81401042),
the National Science and Technology Support Program (2012BAI10B03)
Special Scientific Research Funds for Capital Health Development (2011-1001-01),
Natural Science Foundation of Beijing (7122035).
第一作者机构：[1]Department of Neurobiology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing 100053, China
通讯作者：
通讯机构：[1]Department of Neurobiology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Beijing 100053, China[2]Center of Parkinson’s Disease, Beijing Institute for Brain Disorders, Beijing, China[3]Beijing Key Laboratory for Parkinson’s Disease, Beijing, China
推荐引用方式(GB/T 7714)：
Weiwei Yang,Shun Yu.Synucleinopathies: common features and hippocampal manifestations[J].CELLULAR AND MOLECULAR LIFE SCIENCES.2017,74(8):1485-1501.doi:10.1007/s00018-016-2411-y.
APA：
Weiwei Yang&Shun Yu.(2017).Synucleinopathies: common features and hippocampal manifestations.CELLULAR AND MOLECULAR LIFE SCIENCES,74,(8)
MLA：
Weiwei Yang,et al."Synucleinopathies: common features and hippocampal manifestations".CELLULAR AND MOLECULAR LIFE SCIENCES 74..8(2017):1485-1501
生物学