机构：[1]Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing 100053, China老年医学科首都医科大学宣武医院[2]Key Laboratory on Parkinson’s Disease, Beijing 100053, China[3]Department of Pathology, Guilin Medical College, Guilin 541001, China[4]Wincon TheraCells Biotechnologies Co., Ltd., Nanning 530003, China
In this study, we developed a systemic PD model in middle-aged cynomolgus monkeys using individualized low-dose MPTP, to explore effective indicators for the early prediction of clinical outcomes. MPTP was not stopped until the animals showed typical PD motor symptoms on days 10 to 13 after MPTP administration when the Kurlan score reached 10; this abrogated the differences in individual susceptibility to MPTP. The clinical symptoms persisted, peaking on days 3 to 12 after MPTP withdrawal (rapid progress stage), and then the Kurlan score plateaued. A Kurlan score at the end of the rapid progress stage > 15 reflected stable or slowly-progressive PD, while a score < 15 indicated spontaneous recovery. The entire clinical evolution and outcome of the systemic PD model was characterized in this study, thus providing options for therapeutic and translational research.
基金：
the National High-Tech Development Project of Ministry of Sciences and Technology of China (2012AA020703)
the National Natural Science Foundation of China (31472056),
Scientific Project of the Science and Technology Department of Guangxi Zhuang Autonomous Region, China (1598025-31),
Scientific Project of the Science and Technology Bureau of Nanning Municipality, Guangxi Zhuang Autonomous Region, China (20145194, 20155192).
第一作者机构：[1]Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing 100053, China[2]Key Laboratory on Parkinson’s Disease, Beijing 100053, China
通讯作者：
通讯机构：[1]Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing 100053, China[2]Key Laboratory on Parkinson’s Disease, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Feng Yue,Sien Zeng,Rongping Tang,et al.MPTP Induces Systemic Parkinsonism in Middle-Aged Cynomolgus Monkeys: Clinical Evolution and Outcomes[J].NEUROSCIENCE BULLETIN.2017,33(1):17-27.doi:10.1007/s12264-016-0069-y.
APA：
Feng Yue,Sien Zeng,Rongping Tang,Guoxian Tao&Piu Chan.(2017).MPTP Induces Systemic Parkinsonism in Middle-Aged Cynomolgus Monkeys: Clinical Evolution and Outcomes.NEUROSCIENCE BULLETIN,33,(1)
MLA：
Feng Yue,et al."MPTP Induces Systemic Parkinsonism in Middle-Aged Cynomolgus Monkeys: Clinical Evolution and Outcomes".NEUROSCIENCE BULLETIN 33..1(2017):17-27
