机构：[1]Department of Rheumatology and Immunology, Peking University People’s Hospital, 11 Xizhimen South Street, Beijing 100044, China[2]School of Statistics and The Center for Applied Statistics, Renmin University of China, Beijing 100872, China[3]Department of Rheumatology and Immunology, University Hospital of Hubei University for Nationalities, Enshi 445000, China[4]Department of Rheumatology and Immunology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China[5]Department of Rheumatology and Immunology, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine of Hebei Province, Cangzhou 061001, China[6]Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing 100191, China[7]Department of Rheumatology and Immunology, The First Affiliated Hospital of Baotou Medical College, Baotou 014010, China[8]Department of Rheumatology and Immunology, Hebei Province Central Hospital of Handan City, Handan 056001, China[9]Department of Rheumatology and Immunology, Hebei General Hospital, Shijiazhuang 050051, China[10]Department of Rheumatology and Immunology, Kailuan General Hospital, Tangshan 063000, China[11]Department of Rheumatology and Immunology, Bethune International Peace Hospital, Shijiazhuang 050082, China[12]Department of Rheumatology and Immunology, The Third Affiliated Hospital of Hebei Medical University, Shijiazhuang 050052, China[13]Department of Rheumatology and Clinical Immunology, General Hospital of Tianjin Medical University, Tianjin 300052, China[14]Department of Rheumatology and Immunology, Beijing Hospital, Beijing 100005, China[15]Department of Rheumatology and Immunology, Lanzhou University Second Hospital, Lanzhou 730030, China[16]Department of Rheumatology and Immunology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China[17]Department of Rheumatology and Immunology, China-Japan Friendship Hospital, Beijing 100029, China[18]Department of Rheumatology and Immunology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China[19]Department of Rheumatology and Immunology, Beijing Xuanwu Hospital, Beijing 100053, China风湿免疫科首都医科大学宣武医院[20]Department of Rheumatology and Immunology, The 309th Hospital of Chinese People’s Liberation Army, Beijing 100000, China
Environmental factors play an important role in the development of rheumatoid arthritis (RA). Among these factors, smoking is generally considered to be an established risk factor for RA. Data regarding the impact of diet on risk of RA development is limited. This study assessed the impact of dietary patterns on RA susceptibility in Chinese populations. This was a large scale, case-control study composed of 968 patients with RA and 1037 matched healthy controls. Subjects were recruited from 18 teaching hospitals. Socio-demographic characteristics and dietary intakes 5 years prior to the onset of RA were reported by a self-administered questionnaire. Differences in quantity of consumption between cases and controls were analyzed by Student's t test. Multiple logistic regression analysis was applied to identify independent dietary risk factor(s) responsible for RA susceptibility. Compared to healthy individuals, RA patients had decreased consumption of mushrooms (P = 0.000), beans (P = 0.006), citrus (P = 0.000), poultry (P = 0.000), fish (P = 0.000), edible viscera (P = 0.018), and dairy products (P = 0.005). Multivariate analyses revealed that several dietary items may have protective effects on RA development, such as mushrooms (aOR = 0.669; 95%CI = 0.518-0.864, P = 0.002), citrus fruits (aOR = 0.990; 95%CI = 0.981-0.999, P = 0.04), and dairy products (aOR = 0.921; 95%CI 0.867-0.977, P = 0.006). Several dietary factors had independent effects on RA susceptibility. Dietary interventions may reduce the risk of RA.
基金：
the National Natural Science Foundation of China (No. 81373117 and No. 31270914)
the Beijing Municipal Science & Technology Commission (No. Z131107002213060).
