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Polymorphisms in exon 2 of CD1 genes are associated with susceptibility to Guillain-Barre syndrome

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机构： [a]Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Henan, People's Republic of China [b]Department of Neurosurgery, General Hospital, Tianjin Medical University, Tianjin, People's Republic of China [c]Department of Neurology, Xuanwu Hospital, Affiliated to Capital Medical University, Beijing, People's Republic of China [d]Department of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Henan, People's Republic of China

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关键词： CD1 genes polymorphism Guillain-Barre syndrome Glycolipid presentation

摘要：

Guillain-Barre syndrome (GBS) is a post -infectious autoimmune peripheral neuropathy. Studies have shown that a T cell -mediated immune response to peripheral nerve is associated with the pathogenesis of GBS. CD1 molecules are MCH-like glycoproteins specialized to capture and present glycolipids to T cells. Polymorphisms of CD1 genes may affect susceptibility to GBS. We investigated the polymorphisms of CD1 genes in GBS patients in a Chinese Han population. In 126 patients and in 138 controls we genotyped exon 2 of the CD1A and CD1E genes. The results indicated that polymorphisms of CD1A genes are associated with GBS. Furthermore, subjects with CD1A*01/02 had a 2.9 times lower risk of developing GBS, and those with CD1A*02/02 had a 2.5 times higher risk to developing GBS than the controls, while there was no association between polymorphisms of CD1E genes and the susceptibilities to GBS. (C) 2016 Elsevier B.V. All rights reserved.

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出版当年[2015]版：

大类 | 3 区医学

小类 | 4 区临床神经病学 4 区神经科学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区临床神经病学 3 区神经科学

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出版当年[2014]版：

Q2 CLINICAL NEUROLOGY Q3 NEUROSCIENCES

最新[2023]版：

Q1 CLINICAL NEUROLOGY Q2 NEUROSCIENCES

影响因子： 3.7 最新[2023版] 3.2 最新五年平均 2.474 出版当年[2014版] 2.535 出版当年五年平均 2.262 出版前一年[2013版] 2.126 出版后一年[2015版]

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第一作者机构： [a]Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Henan, People's Republic of China

通讯作者：

通讯机构： [a]Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Henan, People's Republic of China

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