机构：[1]Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.老年医学科首都医科大学宣武医院[2]Wincon TheraCells Biotechnologies Co., LTD, 3 Gaoxin 3 Rd, Nanning 530003, Guangxi, China.[3]Department of Bio-engineering, Guangxi Medical University, 22 Shuangyong Rd, Nanning 530021, Guangxi, China.[4]Guangxi Dongya Center for Nonhuman Primate Research and Technical Development, 3 Gaoxin 3 Rd, Nanning 530003, Guangxi, China.[5]Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
Background: The age-related dysfunction of glucose and lipid metabolism has a long-standing relationship with cardiovascular and neurodegenerative disease. However, the effects of metabolic dysfunction on men and women are different. Reasons for these sex differences remains unclear. Cynomolgus monkeys have been used, in the past, for the study of human metabolic diseases due to their biologically proximity to humans. Nevertheless, few studies to date have focused on both age-and sex-related differences in glucose and lipid metabolism. The present study was designed to specifically address these questions by using a large cohort of cynomolgus monkeys (N = 1,399) including 433 males and 966 females with ages ranging 4 to 24 years old. Methods: Fasting plasma glucose (FPG) and lipid parameters including total cholesterol (T-Cho), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were measured. All these parameters were compared between ages and sexes. Results: Among the entire cohort, age was strongly correlated with levels of FPG, TG and HDL. Consequently, sex-related analysis revealed that females had significantly higher average levels of FPG, T-Cho, TG, HDL-C and LDL-C than their male counterparts. In addition, more female (28.5 %) than male (16 %) monkeys qualified for impaired fasting plasma glucose (IFPG). In those IFPG animals, sex-related differences were also detected i.e. females had significantly increased levels of T-Cho, TG and LDL-C. Conclusions: The result, for the first time, demonstrated the similarities and differences in detail between male and female cynomolgus monkeys in relationship to age-related glucose and lipoprotein metabolisms, and differences under various physiological conditions. The detailed glucose and lipoprotein profiling should provide additional and important insights for prediabetic conditions. Cynomolgus monkeys appear to be an excellent model for translational research of diabetes and for novel therapeutic strategies testing to overt diabetes.
基金：
State High-Tech Development Plan of Ministry of Sciences and Technology of China (2012AA020703),
the National Natural Science Foundation of China (31472056),
the Projects of Science & Technology Department of Guangxi Province of China (13-29-06, 1347004–20),
the Project of Science & Technology Bureau of Nanning of China (20145194).
第一作者机构：[1]Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.[2]Wincon TheraCells Biotechnologies Co., LTD, 3 Gaoxin 3 Rd, Nanning 530003, Guangxi, China.
共同第一作者：
通讯作者：
通讯机构：[5]Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
推荐引用方式(GB/T 7714)：
Feng Yue,Guodong Zhang,Rongping Tang,et al.Age- and sex-related changes in fasting plasma glucose and lipoprotein in cynomolgus monkeys[J].LIPIDS IN HEALTH AND DISEASE.2016,15(1):111.doi:10.1186/s12944-016-0280-x.
APA：
Feng Yue,Guodong Zhang,Rongping Tang,Zhouquan Zhang,Liqiong Teng&Zhiming Zhang.(2016).Age- and sex-related changes in fasting plasma glucose and lipoprotein in cynomolgus monkeys.LIPIDS IN HEALTH AND DISEASE,15,(1)
MLA：
Feng Yue,et al."Age- and sex-related changes in fasting plasma glucose and lipoprotein in cynomolgus monkeys".LIPIDS IN HEALTH AND DISEASE 15..1(2016):111
