机构：[1]Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital University of Medical Science, and Key Laboratory of Neurodegeneration, Ministry of Education, Beijing, China老年医学科首都医科大学宣武医院[2]Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China老年医学科首都医科大学宣武医院
Background Excessive weight gain has been observed in middle-aged cynomolgus monkeys. This study was designed to investigate the metabolic characteristics in overweight monkeys. Methods A total of 26 cynomolgus monkeys were grouped based on gender and body weight. Overweight was operationally defined as body weight heavier than 9.6kg in males and 7.5kg in females. They were monitored for glucose and insulin in fasting state, serum parameters, and somatometric measurements. Results Higher measurements of weight, body mass index (BMI), waist, hip, and waist/hip ratio (WHR) were the somatometric characteristics of overweight monkeys. Abdominal fat deposition was more prominent in females. Elevated total cholesterol, HDL-C, LDL-C, and fasting glucose were observed in female overweight monkeys. Impaired insulin sensitivity occurred in overweight monkeys. Conclusions Overweight could result in impaired insulin sensitivity. The metabolic changes were more prominent in female overweight monkeys.
基金：
State High-Tech Development Plan of Ministry of Sciences and Technology of China (2012AA020703)
Science Research and Technology Development Project from Bureau of Sciences and Technology of Nanning China (201001010A)
high-level talent fund of the Beijing health care (2009-2-14)
第一作者机构：[1]Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital University of Medical Science, and Key Laboratory of Neurodegeneration, Ministry of Education, Beijing, China
通讯作者：
通讯机构：[*1]Department of Neurobiology, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
Di Wu,Feng Yue,Yu A. Zhang.The changes of glucose and lipid metabolism in overweight middle-aged cynomolgus monkeys[J].JOURNAL OF MEDICAL PRIMATOLOGY.2012,41(6):349-355.doi:10.1111/j.1600-0684.2012.00556.x.
APA：
Di Wu,Feng Yue&Yu A. Zhang.(2012).The changes of glucose and lipid metabolism in overweight middle-aged cynomolgus monkeys.JOURNAL OF MEDICAL PRIMATOLOGY,41,(6)
MLA：
Di Wu,et al."The changes of glucose and lipid metabolism in overweight middle-aged cynomolgus monkeys".JOURNAL OF MEDICAL PRIMATOLOGY 41..6(2012):349-355
