The prevalence and incidence of frailty in Pre-diabetic and diabetic community-dwelling older population: results from Beijing longitudinal study of aging II (BLSA-II)
机构：[1]Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, No. 45 Changchun St., Beijing, Xicheng District 100053, China.老年医学科首都医科大学宣武医院[2]Department of Geriatrics, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, No. 45 Changchun St., Beijing, Xicheng District 100053, China.老年医学科首都医科大学宣武医院[3]Department of Neurology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, No. 45 Changchun St., Beijing, Xicheng District 100053, China.神经内科老年医学科首都医科大学宣武医院[4]Parkinson’s Disease Center of Beijing Institute for Brain Disorders, Key Laboratory on Neurodegenerative Disease of Ministry of Education, Beijing Key Laboratory for Parkinson’s Disease, Beijing 100053, China.
Background: Various factors including cardio-metabolic disorders are found to be correlated with frailty. With the increase in age, older adults are likely to have elevated blood glucose level. In this study we intend to investigate the prevalence and incidence of frailty in the pre-diabetic and diabetic community dwelling elderly population and the associated risk factors. Methods: At baseline total of 10,039 subjects with a mean age of 70.51 (+/- 7.82) were included. A total of 6,293 older adults were followed up at 12 months. A Frailty index (FI) with 32 items was developed using Rockwood's cumulative deficits method. Frailty index >= 0.25 was used as cut-off criteria for the diagnosis of frailty. Diagnosis of pre-diabetes and diabetes was set according to the World Health Organization (WHO) criteria for fasting plasma glucose (FPG) level. Chi-square tests were performed to compare percentages by 3 major groups (non-diabetes, pre-diabetes, diabetes), ANOVA and student's t-tests was used to compare means of group for continuous variables. Multiple logistic regression models were performed to estimate the risk factors for frailty in non-diabetic, pre-diabetic and diabetic elderly populations using baseline and longitudinal data. Results: Diabetic population had a much higher prevalence (19.32%) and incidence (12.32%) of frailty, compared to that of non-diabetic older adults (prevalence of 11.92% and incidence of 7.04%). And pre-diabetics had somewhat similar prevalence of 11.43% and slightly higher incidence of 8.73% for frailty than non-diabetic older adults. Diabetics were at 1. 36 (95% CI = 1.18,1.56) and 1.56 (95% CI = 1.32,1.85) fold increase in risk of frailty compared to non-diabetic population for prevalence and incidence, respectively. Being female, urban living, high waist circumference, less house work and need regular anti-diabetic medications were independent risk factors only in pre-diabetic and diabetic older adults. Conclusion: This study confirms that diabetes is an independent serious chronic condition to increase the risk of frailty in community dwelling older adults in northern China. To effectively delay or avoid frailty, older adults should be advised for taking proper control of blood glucose level and avoiding the associated risk factors and implementing the protective factors in primary-care setting.
基金：
Grants D07050701130000 and 07050701130701 from the Beijing Municipal Commission on Science and Technology,
Grant 201002011 from the Ministry of Health of China,
Grants 2012AA02A514, 0S2012GR0150, and2012ZX09303–005 from the Ministry of Science and Technology of China,
Grant ZYLX201301 from the Beijing Municipal Administration of Hospital.
第一作者机构：[2]Department of Geriatrics, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, No. 45 Changchun St., Beijing, Xicheng District 100053, China.
通讯作者：
通讯机构：[1]Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, No. 45 Changchun St., Beijing, Xicheng District 100053, China.[2]Department of Geriatrics, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, No. 45 Changchun St., Beijing, Xicheng District 100053, China.[3]Department of Neurology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, No. 45 Changchun St., Beijing, Xicheng District 100053, China.[4]Parkinson’s Disease Center of Beijing Institute for Brain Disorders, Key Laboratory on Neurodegenerative Disease of Ministry of Education, Beijing Key Laboratory for Parkinson’s Disease, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
Jagadish Kumar Chhetri,Zheng Zheng,Xitong Xu,et al.The prevalence and incidence of frailty in Pre-diabetic and diabetic community-dwelling older population: results from Beijing longitudinal study of aging II (BLSA-II)[J].BMC GERIATRICS.2017,17(1):47.doi:10.1186/s12877-017-0439-y.
APA：
Jagadish Kumar Chhetri,Zheng Zheng,Xitong Xu,Cuihong Ma&Piu Chan.(2017).The prevalence and incidence of frailty in Pre-diabetic and diabetic community-dwelling older population: results from Beijing longitudinal study of aging II (BLSA-II).BMC GERIATRICS,17,(1)
MLA：
Jagadish Kumar Chhetri,et al."The prevalence and incidence of frailty in Pre-diabetic and diabetic community-dwelling older population: results from Beijing longitudinal study of aging II (BLSA-II)".BMC GERIATRICS 17..1(2017):47
医学