机构：[1]Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.[2]Department of Bioengineering, University of California, Los Angeles, California, USA.[3]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China.放射科首都医科大学宣武医院[4]Shenzhen Key Lab for MRI, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Purpose: The purpose of this study was to develop a three-dimensional black blood imaging method for simultaneously evaluating the carotid and intracranial arterial vessel walls with high spatial resolution and excellent blood suppression with and without contrast enhancement. Methods: The delay alternating with nutation for tailored excitation (DANTE) preparation module was incorporated into three-dimensional variable flip angle turbo spin echo (SPACE) sequence to improve blood signal suppression. Simulations and phantom studies were performed to quantify image contrast variations induced by DANTE. DANTE-SPACE, SPACE, and two-dimensional turbo spin echo were compared for apparent signal-to-noise ratio, contrast-to-noise ratio, and morphometric measurements in 14 healthy subjects. Preliminary clinical validation was performed in six symptomatic patients. Results: Apparent residual luminal blood was observed in five (pre-contrast) and nine (post-contrast) subjects with SPACE and only two (post-contrast) subjects with DANTE-SPACE. DANTE-SPACE showed 31% (pre-contrast) and 100% (post-contrast) improvement in wall-to-blood contrast-to-noise ratio over SPACE. Vessel wall area measured from SPACE was significantly larger than that from DANTE-SPACE due to possible residual blood signal contamination. DANTE-SPACE showed the potential to detect vessel wall dissection and identify plaque components in patients. Conclusion: DANTE-SPACE significantly improved arterial and venous blood suppression compared with SPACE. Simultaneous high-resolution carotid and intracranial vessel wall imaging to potentially identify plaque components was feasible with a scan time under 6 min. (C) 2015 Wiley Periodicals, Inc.
基金：
National Heart, Lung, and Blood Institute; (Grant number:R01-HL096119);
National Science Foundation of China;(Grant numbers: 81229001, 81322022).
第一作者机构：[1]Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.[2]Department of Bioengineering, University of California, Los Angeles, California, USA.
通讯作者：
通讯机构：[*1]Cedars-Sinai Medical Center, Biomedical Imaging Research Institute, 8700 Beverly Blvd., PACT Suite 800, Los Angeles, CA, USA 90048
推荐引用方式(GB/T 7714)：
Yibin Xie ,Qi Yang ,Guoxi Xie ,et al.Improved Black-Blood Imaging Using DANTE-SPACE for Simultaneous Carotid and Intracranial Vessel Wall Evaluation[J].MAGNETIC RESONANCE IN MEDICINE.2016,75(6):2286-94.doi:10.1002/mrm.25785.
APA：
Yibin Xie,,Qi Yang,,Guoxi Xie,,Jianing Pang,,Zhaoyang Fan,&Debiao Li.(2016).Improved Black-Blood Imaging Using DANTE-SPACE for Simultaneous Carotid and Intracranial Vessel Wall Evaluation.MAGNETIC RESONANCE IN MEDICINE,75,(6)
MLA：
Yibin Xie,,et al."Improved Black-Blood Imaging Using DANTE-SPACE for Simultaneous Carotid and Intracranial Vessel Wall Evaluation".MAGNETIC RESONANCE IN MEDICINE 75..6(2016):2286-94
