机构：[a]Queen Square MS Centre NMR Research Unit,Department of Neuroinflammation, UCL Institute of Neurology,London,UK[b]Department of Neurology,University Hospital Basel,Basel,Switzerland[c]Department of Neuroscience,Rehabilitation,Ophthalmology,Genetics,Maternal and Child Health,University of Genoa,Genoa,Italy[d]MS Centre of Catalonia(Cemcat),Neurology-Neuroimmunology Department,Vall d’Hebron University Hospital,Barcelona,Spain[e]Department of Molecular Neuroscience,UCL Institute of Neurology,London,UK[f]Division of LifeScience,Hong Kong University of Science and Technology,Hong Kong SAR,China[g]School of Psychology and Cardiff University Brain Research Imaging Centre,Cardiff University,Cardiff,UK[h]School of Psychological Sciences,University of Manchester,Manchester,UK[i]Department of Neurology,Xuanwu Hospital of Capital Medical University,Beijing,China神经内科首都医科大学宣武医院[j]National Institute for Health Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre,UK[k]Brain Repair and Rehabilitation,UCL Institute of Neurology,London,UK[l]Lysholm Department of Neuroradiology,National Hospital for Neurology and Neurosurgery,London,UK
Background: The HLA-DRB*1501 haplotype influences the risk of developing multiple sclerosis (MS), but it is not known how it affects grey matter pathology. Aim: To assess HLA-DRB*1501 effects on magnetic resonance imaging (MRI) cortical grey matter pathology. Methods: Whole and lesional cortical grey matter volumes, lesional and normal-appearing grey matter magnetization transfer ratio were measured in 85 people with MS and 36 healthy control subjects. HLA-DRB*1501 haplotype was determined by genotyping (rs3135388). Results: No significant differences were observed in MRI measures between the HLA-DRB*1501 subgroups. Conclusions: The HLA-DRB*1501 haplotype is not strongly associated with MRI-visible grey matter pathology. (C) 2016 Elsevier B.V. All rights reserved.
基金：
The MS Society of Great Britain and Northern Ireland has provided financial support for staff and research costs(grantno.917-09).
第一作者机构：[a]Queen Square MS Centre NMR Research Unit,Department of Neuroinflammation, UCL Institute of Neurology,London,UK[b]Department of Neurology,University Hospital Basel,Basel,Switzerland
通讯作者：
通讯机构：[a]Queen Square MS Centre NMR Research Unit,Department of Neuroinflammation, UCL Institute of Neurology,London,UK[b]Department of Neurology,University Hospital Basel,Basel,Switzerland
推荐引用方式(GB/T 7714)：
Ozgur Yaldizli,VarunSethi,MatteoPardini,et al.HLA-DRB*1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis[J].MULTIPLE SCLEROSIS AND RELATED DISORDERS.2016,7:47-52.doi:10.1016/j.msard.2016.03.003.
APA：
Ozgur Yaldizli,VarunSethi,MatteoPardini,CarmenTur,KinY.Moke,...&DeclanT.Chard.(2016).HLA-DRB*1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis.MULTIPLE SCLEROSIS AND RELATED DISORDERS,7,
MLA：
Ozgur Yaldizli,et al."HLA-DRB*1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis".MULTIPLE SCLEROSIS AND RELATED DISORDERS 7.(2016):47-52
