Preventing the BDNF and NGF loss involved in the effects of cornel iridoid glycoside on attenuation of experimental autoimmune encephalomyelitis in mice
机构：[1]Xuan Wu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing Geriatric Medical Research Center, Beijing Institute for Brain Disorders, Beijing, P.R. China,神经变性病教育部重点实验室首都医科大学宣武医院[2]Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, P.R. China
The present study was designed to investigate the beneficial effects of cornel iridoid glycoside (CIG), a main component extract from Cornus officinalis, on neurotrophin expression in mouse experimental autoimmune encephalomyelitis (EAE), a classical model of multiple sclerosis (MS). After EAE initiation, CIG was intragastrically administered daily for 32 days and reduced disease severity. Histopathological staining and western blotting both showed that CIG could prevent brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) loss in the spinal cord of EAE mice. In conclusion, our findings indicated that CIG treatment suppressed disease severity of EAE partially through blocking downregulation of neurotrophic factor expression such as BDNF and NGF, suggesting that CIG may have beneficial effects for the treatment of demyelinating diseases such as MS.
基金：
the National Natural Science Foundation of China [grant number 81341088]; [grant number 81273817]; [grant number 81301208];
Beijing Natural Science Foundation [grant number 7162208].
基金编号：grant number 81341088grant number 81273817grant number 81301208grant number 7162208
第一作者机构：[1]Xuan Wu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing Geriatric Medical Research Center, Beijing Institute for Brain Disorders, Beijing, P.R. China,[2]Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, P.R. China
通讯作者：
通讯机构：[1]Xuan Wu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing Geriatric Medical Research Center, Beijing Institute for Brain Disorders, Beijing, P.R. China,[2]Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, P.R. China
推荐引用方式(GB/T 7714)：
Zhao Qu,Na Zheng,Yifan Zhang,et al.Preventing the BDNF and NGF loss involved in the effects of cornel iridoid glycoside on attenuation of experimental autoimmune encephalomyelitis in mice[J].NEUROLOGICAL RESEARCH.2016,38(9):831-837.doi:10.1080/01616412.2016.1200766.
APA：
Zhao Qu,Na Zheng,Yifan Zhang,Li Zhang,Jianghong Liu...&Linlin Yin.(2016).Preventing the BDNF and NGF loss involved in the effects of cornel iridoid glycoside on attenuation of experimental autoimmune encephalomyelitis in mice.NEUROLOGICAL RESEARCH,38,(9)
MLA：
Zhao Qu,et al."Preventing the BDNF and NGF loss involved in the effects of cornel iridoid glycoside on attenuation of experimental autoimmune encephalomyelitis in mice".NEUROLOGICAL RESEARCH 38..9(2016):831-837
