机构：[a]Department of Dermatology and Venereal Disease, Xuanwu Hospital, Capital Medical University, Beijing 100053, China首都医科大学宣武医院[b]Department of Burn and Plastic Surgery, Huai’an First People’s Hospital, Nanjing Medical University, Huai’an 223300, China[c]Department of Medical Oncology, Jinling Hospital, Nanjing 210002, China[d]Department of Dermatology and Venereal Disease, Capital Medical University, Beijing 100069, China
Metastasis is the major problem in malignant melanoma, posing a therapeutic challenge to clinicians. The investigation of the underlying mechanism driving this progress remains a large unmet need. In this study, we revealed a miR-203-BMI1 axis that regulated melanoma metastasis. We found significantly deregulation of miR-203 and up-regulation of BMI1 in melanoma, particularly in metastatic melanoma. An inverse correlation between the levels of miR-203 and BMI1 was further observed in melanoma tissues and cell lines. We also identified BMI1 as a downstream target gene of miR-203, which bound to the 3 ' UTR of BMI1 Overexpression of miR-203 was associated with decreased BMI1 expression and impaired cell invasion and tumor sphere formation activities. Re-expression of BMI1 markedly rescued miR-203-mediated suppression of these events. Taken together, our results demonstrated that miR-203 regulated melanoma invasive and proliferative abilities in part by targeting BMI1, providing new insights into potential mechanisms of melanoma metastasis. (C) 2014 Elsevier Inc. All rights reserved.
第一作者机构：[a]Department of Dermatology and Venereal Disease, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Dermatology and Venereal Disease, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Western District, Beijing 100053, China[*2]Department of Dermatology and Venereal Disease, Capital Medical University, 10 Xitoutiao, YouAnMen, Beijing 100069, China
推荐引用方式(GB/T 7714)：
Xiao Chang,Yong Sun,Siqi Han,et al.miR-203 inhibits melanoma invasive and proliferative abilities by targeting the polycomb group gene BMI1[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2015,456(1):361-366.doi:10.1016/j.bbrc.2014.11.087.
APA：
Xiao Chang,Yong Sun,Siqi Han,Wei Zhu,Haiping Zhang&Shi Lian.(2015).miR-203 inhibits melanoma invasive and proliferative abilities by targeting the polycomb group gene BMI1.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,456,(1)
MLA：
Xiao Chang,et al."miR-203 inhibits melanoma invasive and proliferative abilities by targeting the polycomb group gene BMI1".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 456..1(2015):361-366
