机构：[a]Central Laboratory, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Disease of Ministry of Education, Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, #45 Changchun Street, Xicheng District, Beijing 100053, China首都医科大学宣武医院[b]Department of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China老年医学科首都医科大学宣武医院[c]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China神经内科首都医科大学宣武医院[d]Department of Medical Center, Xuanwu Hospital of Capital Medical University, Beijing, China首都医科大学宣武医院
Alzheimer-associated neuronal thread protein (AD7c-NTP) has been found to be a biomarker for Alzheimer's disease (AD) with elevated levels in the cerebrospinal fluid and urine from AD patients in the early stage of the disease. Whether the urine level of AD7c-NTP in healthy people is age-related is still unclear. We aimed to measure the level of urine AD7c-NTP in a healthy Chinese population of different ages. Urine samples of 294 subjects were collected from the Department of Health Examination Center at Xuanwu Hospital of Capital Medical University, China. The samples were divided into five groups by age: Group 1 (20-29 years), Group 2 (30-39 years), Group 3 (40-49 years), Group 4 (50-59 years) and Group 5 ( >= 60 years). The Mini Mental State Examination and Montreal Cognitive Assessment were carried out. The level of AD7c-NTP in the urine specimen was detected by enzyme-linked immunosorbent assay. The urine AD7c-NTP levels in Group 1, 2, 3, 4 and 5 were 0.3012 +/- 0.2373, 0.3702 +/- 0.2422, 0.3914 +/- 0.2442, 0.4844 +/- 0.2908 and 0.5880 +/- 0.2638 ng/ml (mean +/- standard error of the mean), respectively. The urine AD7c-NTP levels among the five groups differed significantly (F = 6.181, p = 0.00). Females had a higher urine AD7c-NTP content than males, and the urine AD7c-NTP level increased with age (r = 0.28, p = 0.00). To our knowledge this study is the first to show that urine AD7c-NTP level increases with age in a healthy Chinese population without cognitive dysfunction. This study suggests that different cut-off values aimed at different age groups should be established for diagnosing cognitive impairments in clinical practice. (C) 2014 Elsevier Ltd. All rights reserved.
基金：
the Beijing Natural Science Foundation (7132044),
Capital Health Development Research Fund (2011-1001-02),
Ministry of Education in China Project of Humanities and Social Sciences (12YJCZH146),
Beijing Municipal Health Bureau Research Fund (Jing 13-02).
第一作者机构：[a]Central Laboratory, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Disease of Ministry of Education, Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, #45 Changchun Street, Xicheng District, Beijing 100053, China[b]Department of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China
通讯作者：
通讯机构：[a]Central Laboratory, Xuanwu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Disease of Ministry of Education, Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, #45 Changchun Street, Xicheng District, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Lina Ma,Juan Chen,Rong Wang,et al.Alzheimer-associated urine neuronal thread protein level increases with age in a healthy Chinese population[J].JOURNAL OF CLINICAL NEUROSCIENCE.2014,21(12):2118-2121.doi:10.1016/j.jocn.2014.04.028.
APA：
Lina Ma,Juan Chen,Rong Wang,Ying Han,Jingshuang Zhang...&Xi Chu.(2014).Alzheimer-associated urine neuronal thread protein level increases with age in a healthy Chinese population.JOURNAL OF CLINICAL NEUROSCIENCE,21,(12)
MLA：
Lina Ma,et al."Alzheimer-associated urine neuronal thread protein level increases with age in a healthy Chinese population".JOURNAL OF CLINICAL NEUROSCIENCE 21..12(2014):2118-2121
