机构：[1]Central Laboratory, Xuanwu Hospital, Capital Medical University, Beijing 100053, China首都医科大学宣武医院中心实验室[2]Evidence-Based Medical Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China首都医科大学宣武医院循证医学中心[3]Beijing Geriatric Medical Research Center, Beijing 100053, China[4]Clinical Laboratory, Affiliated Hospital of Guilin Medical University, Guilin 541001, China[5]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China神经科系统神经内科首都医科大学宣武医院[6]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing 100053, China
Urinary Alzheimer-associated neuronal thread protein (AD7c-NTP) is elevated in early Alzheimer's disease (AD) and mild cognitive impairment, and is considered a biomarker for the early diagnosis of AD. However, it has not yet been investigated whether urinary AD7c-NTP is elevated with increases in blood biochemical indicators related to AD risk factors. We recruited 2180 participants, aged 35-93 years, from communities of four districts in Beijing. Blood biochemical indicators, including blood glucose, blood lipids, renal function, and high-sensitivity C-reactive protein, were measured using routine methods. Urinary AD7c-NTP was detected using an enzyme-linked immunosorbent assay AD7c-NTP kit. In the general population, there were no significant differences in urinary AD7c-NTP levels in subjects with different Mini-Mental State Examination levels or C-reactive protein values. After adjusting for age and sex, there were significant differences in urinary AD7c-NTP levels between different education levels, marital statuses, blood glucose, blood lipids, and kidney function. There was a negative correlation between urinary AD7c-NTP levels and serum creatinine (r = -0.128). There was a positive correlation between urinary AD7c-NTP levels and HbA1c (r = 0.104), insulin (r = 0.101), and triglycerides (r = 0.093). Urinary AD7c-NTP might be useful as a potential indicator to predict AD risk.
基金：
This article was supported by the National Key Research
and Development Program of China (2016YFC1306302,
2018YFC1312001, 2018YFA0108503), National Natural
Science Foundation of China (Grant 61633018,
81801052), Beijing Municipal Administration of
Hospitals Clinical Medicine Development of Special
Funding Support (ZYLX201706), Beijing Municipal
Commission of Health and Family Planning (PXM2020_
026283_000002), China Postdoctoral Science Foundation
(2018M641414), Beijing Postdoctoral Research Foundation(ZZ2019-12), Xuan Wu Hospital, Capital
Medical University No. XWJL-2019004 and the Capital
Health Research and Development of Special (grant
no.2014-1-1031).
第一作者机构：[1]Central Laboratory, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
通讯作者：
推荐引用方式(GB/T 7714)：
Li Yuxia,Guan Shaochen,Jin He,et al.The relationship between urinary Alzheimer-associated neuronal thread protein and blood biochemical indicators in the general population.[J].AGING-US.2020,12(15):15260-15280.doi:10.18632/aging.103356.
APA：
Li Yuxia,Guan Shaochen,Jin He,Liu Hongjun,Kang Meimei...&Wang Rong.(2020).The relationship between urinary Alzheimer-associated neuronal thread protein and blood biochemical indicators in the general population..AGING-US,12,(15)
MLA：
Li Yuxia,et al."The relationship between urinary Alzheimer-associated neuronal thread protein and blood biochemical indicators in the general population.".AGING-US 12..15(2020):15260-15280
