机构：[a]Center of the Treatment in Depressive Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China[b]Department of Radiology, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China[c]Beijing Key Laboratory of Mental Disorders, Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, No. 5 Ankang Lane, DewaiAvenue, Xicheng District, Beijing 100088, China[d]School of Biomedical Engineering, Capital Medical University, Beijing 100069, China[e]Center of Schizophrenia, Beijing Institute for Brain Disorders, Laboratory of Brain Disorders, Capital Medical University, Ministry of Science and Technology.Beijing 100088, China[f]Department of Neurplogy, Xuanwu Hospital, Capital Medical University, Beijing 100053, China首都医科大学宣武医院[g]Beijing Key Laboratory of Neuromodulation, Capital Medical University, Beijing 100053, China[h]Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China
Bipolar depression (BD) is a common psychiatric illness characterized by deficits in emotional and cognitive processing. Abnormalities in the subregions of the insula are common findings in neuroanatomical studies of patients with bipolar disorder. However, the specific relationships between morphometric changes in specific insular subregions and the pathogenesis of BD are not clear. In this study, structural magnetic resonance imaging (MRI) was used to investigate gray matter volume abnormalities in the insular subregion in 27 patients with BD and in 27 age and sex-matched controls. Using DARTEL (diffeomorphic anatomical registration through exponentiated lie algebra) for voxel-based morphometry (VBM), we examined changes in regional gray matter volumes of the insula in patients with BD. As compared with healthy controls, the BD patients showed decreased gray matter volumes in the right posterior insula and left ventral anterior insula and increased gray matter volumes in the left dorsal anterior insula. Consistent with the emerging theory of insular interference as a contributor to emotional-cognitive dysregulation, the current findings suggest that the insular cortex may be involved in the neural substrates of BD. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
基金：
the Program for Science andTechnology of Beijing (Grant no. D12 110OO05012002),
the NationalNatural Science Foundation of China (Grant no.81471389),
the Open Project of Key Laboratory Incubation Base (Grant no.2013NBTK01),
the Capital Medical University Fundamentaland Clinical Foundations of China (Grant no. 14JL87O)
第一作者机构：[a]Center of the Treatment in Depressive Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China[b]Department of Radiology, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China
共同第一作者：
通讯作者：
通讯机构：[*1]Beijing Key Laboratory of Mental Disorders,Department of Psychiatry,Beijing Anding Hospital,Capital Medical University,No. 5 AnkangLane,Dewai Avenue,Xicheng District,Beijing 100088,China.
推荐引用方式(GB/T 7714)：
Li-Rong Tang,Chun-Hong Liu,Bin Jing,et al.Voxel-based morphometry study of the insular cortex in bipolar depression[J].PSYCHIATRY RESEARCH-NEUROIMAGING.2014,224(2):89-95.doi:10.1016/j.pscychresns.2014.08.004.
APA：
Li-Rong Tang,Chun-Hong Liu,Bin Jing,Xin Ma,Hai-Yun Li...&Chuan-Yue Wang.(2014).Voxel-based morphometry study of the insular cortex in bipolar depression.PSYCHIATRY RESEARCH-NEUROIMAGING,224,(2)
MLA：
Li-Rong Tang,et al."Voxel-based morphometry study of the insular cortex in bipolar depression".PSYCHIATRY RESEARCH-NEUROIMAGING 224..2(2014):89-95
