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Expansion of the polyQ repeats in THAP11 forms intranuclear aggregation and causes cell G0/G1 arrest

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收录情况： ◇ SCIE

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机构： [1]Beijing Institute of Radiation Medicine, Beijing 100850, China [2]Department of Pathophysiology, Anhui Medical University, HeFei 230000, China [3]State Key laboratory of Proteomics, Beijing 100850, China [4]Department of Neurology, Beijing Institute of Geriatrics, Xuanwu Hospital, Beijing 100053, China [5]Department of Biological Sciences, Purdue University, 915 W. State Street, West Lafayette, IN 47907-2054, USA [6]Department of Pulmonary Neoplasms Internal Medicine, Affiliated Hospital of Academy of the Military Medicine Science, Beijing 100071, China

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关键词： cell cycle arrest intracellular aggregation polyglutamine expansion THAP11

摘要：

Polyglutamine diseases are a group of neurodegenerative disorders caused by expansion of a CAG repeat that encodes polyglutamine in each respective disease gene. The transcription factor THAP11, a member of THAP family, is involved in cell growth, ES cell pluripotency and embryogenesis. Previous studies suggest that THAP11 protein contains a 29-residue repeat polyglutamine motif and the number of polyglutamine ranges from 20 to 41 in Indian population. We have investigated the CAG numbers at the THAP11 locus in normal individuals and neurodegenerative disease patients of Chinese Han population and a 38Q expansion (THAP11(38Q)) was found in patients. Using fluorescence confocal-based cell imaging, THAP11(38Q) protein formed intranuclear inclusions easier than THAP11(29Q) in PC12 cells. Enhanced toxicity was investigated in THAP11(38Q)-expressing cells by growth inhibition and G0/G1 arrest. CREB-mediated transcription activity was inhibited by THAP11(38Q). The transcription factor, TBP, coactivator CBP, and chaperon protein, HSP70, could be recruited to THAP11(38Q). These results indicate that expansion of the polyglutamine in THAP11 forms intracellular aggregation and is toxic in PC12 cells, suggesting a putative role of THAP11 in polyglutamine disease.

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出版当年[2013]版：

大类 | 4 区生物

小类 | 4 区细胞生物学

最新[2025]版：

大类 | 3 区生物学

小类 | 4 区细胞生物学

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出版当年[2012]版：

Q4 CELL BIOLOGY

最新[2023]版：

Q3 CELL BIOLOGY

影响因子： 3.3 最新[2023版] 3.6 最新五年平均 1.64 出版当年[2012版] 1.681 出版当年五年平均 1.482 出版前一年[2011版] 1.635 出版后一年[2013版]

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第一作者机构： [1]Beijing Institute of Radiation Medicine, Beijing 100850, China

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通讯机构： [1]Beijing Institute of Radiation Medicine, Beijing 100850, China [3]State Key laboratory of Proteomics, Beijing 100850, China

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