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Ischemic post-conditioning facilitates brain recovery after stroke by promoting Akt/mTOR activity in nude rats

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机构： [1]Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA [2]Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China [3]Department of Neurosurgery, Shanghai Jingan District Central Hospital, Shanghai, China [4]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China [5]Stanford Stroke Center, Stanford University School of Medicine, Stanford, California, USA

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关键词： Akt ischemic post-conditioning mTOR stroke T cells

摘要：

While pre-conditioning is induced before stroke onset, ischemic post-conditioning (IPostC) is performed after reperfusion, which typically refers to a series of mechanical interruption of blood reperfusion after stroke. IPostC is known to reduce infarction in wild-type animals. We investigated if IPostC protects against brain injury induced by focal ischemia in Tcell-deficient nude rats and to examine its effects on Akt and the mammalian target of rapamycin (mTOR) pathway. Although IPostC reduced infarct size at 2days post-stroke in wild-type rats, it did not attenuate infarction in nude rats. Despite the unaltered infarct size in nude rats, IPostC increased levels of phosphorylated Akt (p-Akt) and Akt isoforms (Akt1, Akt2, Akt3), and p-mTOR, p-S6K and p-4EBP1 in the mTOR pathway, as well as growth associated Protein 43 (GAP43), both in the peri-infarct area and core, 24h after stroke. IPostC improved neurological function in nude rats 1-30days after stroke and reduced the extent of brain damage 30days after stroke. The mTOR inhibitor rapamycin abolished the long-term protective effects of IPostC. We determined that IPostC did not inhibit acute infarction in nude rats but did provide long-term protection by enhancing Akt and mTOR activity during the acute post-stroke phase.

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出版当年[2012]版：

大类 | 2 区

医学

小类 | 3 区生化与分子生物学 3 区神经科学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区生化与分子生物学 3 区神经科学

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出版当年[2011]版：

Q1 NEUROSCIENCES Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 NEUROSCIENCES

影响因子： 4.2 最新[2023版] 4.9 最新五年平均 4.061 出版当年[2011版] 4.201 出版当年五年平均 4.337 出版前一年[2010版] 3.973 出版后一年[2012版]

第一作者：

第一作者机构： [1]Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA [2]Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China [3]Department of Neurosurgery, Shanghai Jingan District Central Hospital, Shanghai, China

通讯作者：

通讯机构： [*1]Department of Neurosurgery, Stanford University School of Medicine, MSLS Bldg., Room P306, 1201 Welch Rd., Stanford, CA 94305-5327, USA.

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Ischemic post-conditioning facilitates brain recovery after stroke by promoting Akt/mTOR activity in nude rats

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