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Remote ischemic post-conditioning reduced brain damage in experimental ischemia/reperfusion injury

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机构： [1]Institute of Hypoxia Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China, [2]Department of Neurosurgery, The Affiliated Hospital of Weifang Medical College, China, [3]Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, USA, [4]Institute of Cerebrovascular Disease, Xuanwu Hospital, Capital Medical University, Beijing, China, [5]Xuanwu Hospital, Capital Medical University, Beijing, China

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关键词： Ischemia/reperfusion injury Remote post-conditioning Stroke

摘要：

Objectives: To determine the protective effects of remote post-conditioning on ischemic brain lesions caused by middle cerebral artery (MCA) occlusion in rats. Methods: A total of 54 animals were used in this present study. An ischemic stroke model was generated by 90-minute occlusion of right MCA (n=42). Twelve rats were used as control for studying edema and blood-brain barrier (BBB) integrity. Remote post-conditioning was conducted immediately after MCA occlusion in the bilateral lower limb by occluding and releasing the femoral artery for three cycles; each occlusion and release lasted for 10 minutes. After 24 hours of reperfusion, the cerebral infarct volumes were quantified by 2,3,4-triphenytetrazolium-chloride, brain water content was determined by dry/wet weight method, and damage to the BBB was determined by Evans blue extravasation. Results: Remote post-conditioning significantly reduced brain infarct damage (P<0.0001). Brain edema was significantly (P<0.01) reduced after stroke in the remote post-conditioning group. BBB leakage was significantly reduced in the remote post-conditioning group when compared to the control ischemic groups (P<0.05). Conclusion: These results provide evidence that remote post-conditioning, which was initiated after ischemia and before reperfusion, protects against brain injury in experimental ischemic stroke.

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出版当年[2010]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区神经科学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区神经科学

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出版当年[2009]版：

Q3 CLINICAL NEUROLOGY Q4 NEUROSCIENCES

最新[2023]版：

Q3 CLINICAL NEUROLOGY Q4 NEUROSCIENCES

影响因子： 1.7 最新[2023版] 2.2 最新五年平均 1.277 出版当年[2009版] 1.884 出版当年五年平均 1.634 出版前一年[2008版] 1.621 出版后一年[2010版]

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第一作者机构： [1]Institute of Hypoxia Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China,

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通讯机构： [*]Xuanwu Hospital, Capital Medical University, Chang Chun Road 45, Beijing 100053, China

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