机构:[1]Cerebrovascular Diseases Research Institute,Xuanwu Hospital,Capita/Medical University,Ministry of Education,Beijing 100053,China首都医科大学?脑血管病研究所首都医科大学宣武医院[2]Department of Neurology,Xuanwu Hospital of Capital Medical University,Capital Medical University,Ministry of Education,Beijng 100053 China神经内科首都医科大学宣武医院[3]Key Laboratry of Neurodegenerative Diseases,Capital Medical University,Ministry of Education,Beijing 100053,China[4]Department of Neurology,Afifiated Hospital of Liaoning Medical University,Jinzhou 121000,Liaoning Province,China
Three cycles of remote ischemic pre-conditioning induced by temporarily occluding the bilateral femoral arteries (10 minutes) prior to 10 minutes of reperfusion were given once a day for 3 days before the animal received middle artery occlusion and reperfusion surgery. The results showed that brain infarct volume was significantly reduced after remote ischemic pre-conditioning. Scores in the forelimb placing test and the postural reflex test were significantly lower in rats having undergone remote ischemic pre-conditioning compared with those who did not receive remote ischemic pre-conditioning. Thus, neurological function was better in rats having undergone remote ischemic pre-conditioning compared with those who did not receive remote ischemic pre-conditioning. These results indicate that remote ischemic pre-conditioning in rat hindlimb exerts protective effects in ischemia-reperfusion injury.
基金:
the National Natural Science Foundation of China(No.30870854,No.30770743,No.81071058)
第一作者机构:[1]Cerebrovascular Diseases Research Institute,Xuanwu Hospital,Capita/Medical University,Ministry of Education,Beijing 100053,China[2]Department of Neurology,Xuanwu Hospital of Capital Medical University,Capital Medical University,Ministry of Education,Beijng 100053 China
通讯作者:
通讯机构:[*1]Cerebrovascular Diseases Research Institute,Xuanwu Hospita1,Capital Medical University,M inistry of Education,Beijing 100053, China,Key Laboratory of Neurodegenerative Diseases CapitaI Medical University,M inistry of Education.Beijing 100053, China
推荐引用方式(GB/T 7714):
Ying Zhang,Xiangrong Liu,Feng Yan,et al.Protective effects of remote ischemic preconditioning in rat hindlimb on ischemia-reperfusion injury[J].NEURAL REGENERATION RESEARCH.2012,7(8):583-587.doi:10.3969/j.issn.1673-5374.2012.00.004.
APA:
Ying Zhang,Xiangrong Liu,Feng Yan,Lianqiu Min,Xunming Ji&Yumin Luo.(2012).Protective effects of remote ischemic preconditioning in rat hindlimb on ischemia-reperfusion injury.NEURAL REGENERATION RESEARCH,7,(8)
MLA:
Ying Zhang,et al."Protective effects of remote ischemic preconditioning in rat hindlimb on ischemia-reperfusion injury".NEURAL REGENERATION RESEARCH 7..8(2012):583-587