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Protective effects of remote ischemic preconditioning in rat hindlimb on ischemia-reperfusion injury

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机构: [1]Cerebrovascular Diseases Research Institute,Xuanwu Hospital,Capita/Medical University,Ministry of Education,Beijing 100053,China [2]Department of Neurology,Xuanwu Hospital of Capital Medical University,Capital Medical University,Ministry of Education,Beijng 100053 China [3]Key Laboratry of Neurodegenerative Diseases,Capital Medical University,Ministry of Education,Beijing 100053,China [4]Department of Neurology,Afifiated Hospital of Liaoning Medical University,Jinzhou 121000,Liaoning Province,China
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关键词: cerebral ischemia-reperfusion remote ischemic preconditioning stroke neural regeneration

摘要:
Three cycles of remote ischemic pre-conditioning induced by temporarily occluding the bilateral femoral arteries (10 minutes) prior to 10 minutes of reperfusion were given once a day for 3 days before the animal received middle artery occlusion and reperfusion surgery. The results showed that brain infarct volume was significantly reduced after remote ischemic pre-conditioning. Scores in the forelimb placing test and the postural reflex test were significantly lower in rats having undergone remote ischemic pre-conditioning compared with those who did not receive remote ischemic pre-conditioning. Thus, neurological function was better in rats having undergone remote ischemic pre-conditioning compared with those who did not receive remote ischemic pre-conditioning. These results indicate that remote ischemic pre-conditioning in rat hindlimb exerts protective effects in ischemia-reperfusion injury.

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出版当年[2011]版:
大类 | 4 区 医学
小类 | 4 区 细胞生物学 4 区 神经科学
最新[2023]版:
大类 | 2 区 医学
小类 | 3 区 细胞生物学 3 区 神经科学
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出版当年[2010]版:
Q4 CELL BIOLOGY Q4 NEUROSCIENCES
最新[2023]版:
Q1 NEUROSCIENCES Q2 CELL BIOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2010版] 出版当年五年平均 出版前一年[2009版] 出版后一年[2011版]

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第一作者机构: [1]Cerebrovascular Diseases Research Institute,Xuanwu Hospital,Capita/Medical University,Ministry of Education,Beijing 100053,China [2]Department of Neurology,Xuanwu Hospital of Capital Medical University,Capital Medical University,Ministry of Education,Beijng 100053 China
通讯作者:
通讯机构: [*1]Cerebrovascular Diseases Research Institute,Xuanwu Hospita1,Capital Medical University,M inistry of Education,Beijing 100053, China,Key Laboratory of Neurodegenerative Diseases CapitaI Medical University,M inistry of Education.Beijing 100053, China
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