机构：[1]School of Mat. Sci. & Eng., Beihang University, Beijing 100191, China[2]Institute of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China血管外科首都医科大学宣武医院[3]School of chemical sciences, Inner Mongolia Normal University, Huhhot 010000, China
Magnesium alloys have a good application prospect in the fields of bone implants and cardiovascular stents due to their excellent properties, such as close density and elastic modulus to those of nature bone, high specific strength and rigidity, biodegradation and biocompatibility. In this paper, the feasibility of the use of the forged Mg-Li-X alloys (Mg-Li-Al-Zn-Ca-Sr) as biodegradable metals was investigated by immersion tests in the Hank's solution and skin-tissue implantation tests. The methods of SEM-EDS and XRD were used to research the corrosion morphology and corrosion products of the forged Mg-Li-X alloys after the in-vitro and in-vivo tests. At last, the in-vitro cytotoxicity was investigated by the MTT tests on L929 cells. Results showed that corrosion mechanism of the forged Mg-Li alloys was pitting and the surfaces were covered by Mg(OH)(2), CaCO3 and Ca(H2PO4)(2). During the 5 weeks implantation period, the rats survived from the operation, which indicates that the elements and the compounds formed are non-toxic to the rats. The forged Mg-Li alloy showed Grade 0 similar to 1 cytotoxicity, which manifests the forged Mg-Li alloy has good biocompatibility and eligible toxicity for implant applications.
基金：
Natural Science Fund of Inner Mongolia autonomous region(2011MS0206)
语种：
外文
被引次数：
WOS：
第一作者：
第一作者机构：[1]School of Mat. Sci. & Eng., Beihang University, Beijing 100191, China
推荐引用方式(GB/T 7714)：
Sha Luo,Qingqing Zhang,Yanchang Zhang,et al.In Vitro and in Vivo Studies on a Mg-Li-X Alloy System Developed as a New Kind of Biological Metal[J].HIGH PERFORMANCE STRUCTURE MATERIALS.2013,747-748:doi:10.4028/www.scientific.net/MSF.747-748.257.
APA：
Sha Luo,Qingqing Zhang,Yanchang Zhang,Chao Li,Xiaoqing Xu&Tietao Zhou.(2013).In Vitro and in Vivo Studies on a Mg-Li-X Alloy System Developed as a New Kind of Biological Metal.HIGH PERFORMANCE STRUCTURE MATERIALS,747-748,
MLA：
Sha Luo,et al."In Vitro and in Vivo Studies on a Mg-Li-X Alloy System Developed as a New Kind of Biological Metal".HIGH PERFORMANCE STRUCTURE MATERIALS 747-748.(2013)
