beta-Type titanium alloys with a low elastic modulus are a potential strategy to enhance bone remodeling and to mitigate the concern over the risks of osteanabrosis and bone resorption caused by stress shielding, when used to substitute irreversibly impaired hard tissue. Hence, in this study, a Ti-45Nb alloy with low Young's modulus and high strength was developed, and microstructure, mechanical properties, corrosion behaviors, cytocompatibility and in vivo osteo-compatibility of the alloy were systematically investigated for the first time. The results of mechanical tests showed that Young's modulus of the Ti-Nb alloy was reduced to about 64.3 GPa (close to human cortical bone) accompanied with higher tensile strength and hardness compared with those of pure Ti. Importantly, the Ti-Nb alloy exhibited superior corrosion resistance to Ti in different solutions including SBF, MAS and FAAS (MAS containing NaF) media. In addition, the Ti-Nb alloy produced no deleterious effect to L929 and MG-63 cells, and cells performed excellent cell attachment onto Ti-Nb surface, indicating a good in vitro cytocompatibility. In vivo evaluations indicated that Ti-Nb had comparable bone tissue compatibility to Ti determined from micro-CT and histological evaluations. The Ti-Nb alloy with an elasticity close to human bone, thus, could be suitable for orthopedic/dental applications. (C) 2015 Elsevier B.V. All rights reserved.
基金：
Natural Science Foundation of ChinaNational Natural Science Foundation of China [30973317]; Peking University's 985 Grant
第一作者机构：[1]Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Lab Interdisciplinary Studies, Beijing 100081, Peoples R China;[2]China Med Univ, Aviat Gen Hosp, Dept Stomatol, Beijing 100012, Peoples R China;[3]Chinese Acad Sci, Beijing Inst Translat Med, Beijing 100012, Peoples R China;
通讯作者：
通讯机构：[2]China Med Univ, Aviat Gen Hosp, Dept Stomatol, Beijing 100012, Peoples R China;[3]Chinese Acad Sci, Beijing Inst Translat Med, Beijing 100012, Peoples R China;
推荐引用方式(GB/T 7714)：
Bai Yanjie,Deng Yi,Zheng Yunfei,et al.Characterization, corrosion behavior, cellular response and in vivo bone tissue compatibility of titanium-niobium alloy with low Young's modulus[J].MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS.2016,59:565-576.doi:10.1016/j.msec.2015.10.062.
APA：
Bai, Yanjie,Deng, Yi,Zheng, Yunfei,Li, Yongliang,Zhang, Ranran...&Wei, Shicheng.(2016).Characterization, corrosion behavior, cellular response and in vivo bone tissue compatibility of titanium-niobium alloy with low Young's modulus.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,59,
MLA：
Bai, Yanjie,et al."Characterization, corrosion behavior, cellular response and in vivo bone tissue compatibility of titanium-niobium alloy with low Young's modulus".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 59.(2016):565-576
