机构：[1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China神经外科首都医科大学宣武医院[2]Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI
Background and Purpose-We investigated the potential benefit of using a local infusion of low-dose and cold human albumin in ischemic rats as compared with systemic delivery. Methods-Stroke was induced in rats, and at 2 hours treatment groups received 0 degrees C saline or low-dose albumin at 0 degrees C or 37 degrees C infused into the ischemic area. Results-The local low-dose cold albumin infusion, which achieved the hypothermic temperature (P<0.001), produced the greatest reduction in infarct volume and the best recovery of neurological function. Conclusions-The local low-dose cold albumin infusion into the ischemic area offered a combination of regional brain hypothermia and albumin administration, which enhanced neuroprotection and would be beneficial in the clinical setting. (Stroke. 2013;44:260-262.)
基金：
National Nature Science Foundation of China (No. NSFC81070927)
the National High-Tech Program of China (863Program, No. 2006AA02Z497)
第一作者机构：[1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[*1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, 45 Chang Chun Street, Beijing, 100053, China
推荐引用方式(GB/T 7714)：
Jian Chen,Vance Fredrickson,Yuchuan Ding,et al.Enhanced Neuroprotection by Local Intra-Arterial Infusion of Human Albumin Solution and Local Hypothermia[J].STROKE.2013,44(1):260-262.doi:10.1161/STROKEAHA.112.675462.
APA：
Jian Chen,Vance Fredrickson,Yuchuan Ding,Huakun Cheng,Ning Wang...&Xunming Ji.(2013).Enhanced Neuroprotection by Local Intra-Arterial Infusion of Human Albumin Solution and Local Hypothermia.STROKE,44,(1)
MLA：
Jian Chen,et al."Enhanced Neuroprotection by Local Intra-Arterial Infusion of Human Albumin Solution and Local Hypothermia".STROKE 44..1(2013):260-262
医学