机构：[a]Department of Neurology, Xuan Wu Hospital of the Capital Medical University, 45 Changchun Street, Beijing 100053, PR China神经内科首都医科大学宣武医院[b]Key Neurodegenerative Laboratory of Ministry of Education of the People’s Republic of China, 45 Changchun Street, Beijing 100053, PR China[c]Department of Computer Science, University of Otago, 364 Leith Walk, PO Box 56, Dunedin 9054, New Zealand
Although numerous studies have been carried out to determine the effects of sex hormones on Alzheimer's disease (AD), little is known about the associations between sex hormones and VaD. The aim of this study was to compare serum sex hormone levels between VaD patients and normal controls, and to further determine the link between sex hormones and cognitive and neuropsychiatric manifestations of VaD. Serum levels of total estradiol (TE2), total testosterone (TT), luteinizing hormone (LH), and sex hormone binding globulin (SHBG) were measured in 87 VaD patients and 110 cognitive normal controls. The levels of bioavailable estradiol (BE2) and bioavailable testosterone (BT) were calculated. The VaD patients underwent the tests of global cognitive function, verbal memory, and visuospatial, and executive ability. The Neuropsychiatric Inventory (NPI) was used to assess neuropsychiatric symptoms. Compared to controls, the testosterone and SHBG levels were lower in male VaD patients, and the estradiol levels were higher in female VaD patients. The hormones levels were not correlated with cognitive functions among either male or female VaD patients. There were no associations between hormone levels and neuropsychiatric symptoms among male patients, while the TE2 and TT levels were positively associated with apathy and anxiety, respectively among female patients. Our findings suggested there were sex hormone level changes in VaD patients in comparison with cognitive normal controls. Sex hormones were associated with neuropsychiatric symptoms among female but not male VaD patients. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
基金：
National Key Technology R&D Program in the Eleventh Five-year Plan Period (2006BAI02B01)
the key project of the National Natural Science Foundation of China (30830045)
the National High Technology Research and Development Program 863 (2006AA02A408)
the National Science and Technology Major Projects for ‘‘Major New Drugs Innovation and Development’’ in the Twelfth Five-year Plan Period (2011ZX09307-001-02)
the key project of Science and Technology Plan of Beijing Municipal Education Commission (KZ201010025023 and KZ200910025005)
the major project of Science and Technology Plan of Beijing Municipal Science & Technology Commission (SCW 2011-10)
第一作者机构：[a]Department of Neurology, Xuan Wu Hospital of the Capital Medical University, 45 Changchun Street, Beijing 100053, PR China[b]Key Neurodegenerative Laboratory of Ministry of Education of the People’s Republic of China, 45 Changchun Street, Beijing 100053, PR China
通讯作者：
通讯机构：[*1]Department of Neurology, Xuan Wu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, PR China.
推荐引用方式(GB/T 7714)：
Yi Xing,Wei Qin,Fang Li,et al.Associations between sex hormones and cognitive and neuropsychiatric manifestations in vascular dementia (VaD)[J].ARCHIVES OF GERONTOLOGY AND GERIATRICS.2013,56(1):85-90.doi:10.1016/j.archger.2012.10.003.
APA：
Yi Xing,Wei Qin,Fang Li,Xiang-Fei Jia&Jianping Jia.(2013).Associations between sex hormones and cognitive and neuropsychiatric manifestations in vascular dementia (VaD).ARCHIVES OF GERONTOLOGY AND GERIATRICS,56,(1)
MLA：
Yi Xing,et al."Associations between sex hormones and cognitive and neuropsychiatric manifestations in vascular dementia (VaD)".ARCHIVES OF GERONTOLOGY AND GERIATRICS 56..1(2013):85-90
