机构：[a]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China放射科首都医科大学宣武医院[b]Centre for Neuroscience, University of Melbourne, Parkville, Victoria 3010, Australia[c]Department of Radiology, Royal Melbourne Hospital, Melbourne, Australia[d]Department of Neurology, Royal Melbourne Hospital, Melbourne, Australia[e]Florey Neuroscience Institutes, Melbourne, Australia[f]Department of Diabetes and Endocrinology, Royal Melbourne Hospital, Melbourne, Australia[g]Division of Autoimmunity and Transplantation, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia[h]Department of Paediatrics, Monash University, Melbourne, Australia[i]Department of Medicine, Royal Melbourne Hospital Academic Centre, University of Melbourne, Melbourne, Australia
The initiating events in multiple sclerosis (MS) plaque formation are poorly understood. Retrospective analysis of serial imaging data can improve the understanding of tissue changes characterising acute MS lesion evolution. This study aimed to assess lesion evolution using diffusion tensor imaging data from serially acquired scans from 22 patients with MS. Mean diffusivity (MD) and fractional anisotropy (FA) were measured from 13 suitable plaques from five patients and carefully matched regions of contralateral normal-appearing white matter. Measurement times were on average: 5 months and 1 month prior to, during, and 1 month and 2 months post gadolinium-enhancement. A significant increase in MD (7.25%) but no change in FA was observed in white matter areas that exhibited enhancement 5 months later. The pre-lesional MD increase was significantly correlated with the MD increase 2 months subsequent to enhancement (R = 0.73, p = 0.04) but not to the MD increase during enhancement (R = 0.11). These results suggest that MD is sensitive to tissue changes that precede blood-brain barrier (BOB) breakdown by at least 5 months and that MD assessments may predict injury following BBB restoration. (C) 2012 Elsevier Ltd. All rights reserved.
基金：
the Myer Foundation as well as the McDonald Fellowship from the Multiple Sclerosis International Federation (MSIF)
the National Science Foundation of China (Nos 81101038,30930029)
the Australian National Health and Medical Research Council (NHMRC)
Principal Research Fellowship (Grant 400317, G. F. Egan)
Australia, the joint MS Research Australia / Trish MS Foundation / NHMRC Betty Cuthbert Fellowship (Grant 400476)
the joint MS Research Australia / Australian Financial Advisors Association Postgraduate Scholarship Charityworks
the Neurosciences Victoria Neuro-informatics Platform
第一作者机构：[a]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China[b]Centre for Neuroscience, University of Melbourne, Parkville, Victoria 3010, Australia
通讯作者：
通讯机构：[b]Centre for Neuroscience, University of Melbourne, Parkville, Victoria 3010, Australia[e]Florey Neuroscience Institutes, Melbourne, Australia
推荐引用方式(GB/T 7714)：
Y. Liu,P.J. Mitchell,T.J. Kilpatrick,et al.Diffusion tensor imaging of acute inflammatory lesion evolution in multiple sclerosis[J].JOURNAL OF CLINICAL NEUROSCIENCE.2012,19(12):1689-1694.doi:10.1016/j.jocn.2012.03.022.
APA：
Y. Liu,P.J. Mitchell,T.J. Kilpatrick,M.S. Stein,L.C. Harrison...&S.C. Kolbe.(2012).Diffusion tensor imaging of acute inflammatory lesion evolution in multiple sclerosis.JOURNAL OF CLINICAL NEUROSCIENCE,19,(12)
MLA：
Y. Liu,et al."Diffusion tensor imaging of acute inflammatory lesion evolution in multiple sclerosis".JOURNAL OF CLINICAL NEUROSCIENCE 19..12(2012):1689-1694
